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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1997-10-20
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pubmed:abstractText |
Ketolides belong to a new class of semi-synthetic 14-membered-ring macrolides, which differ from erythromycin A by having a 3-keto group instead of the neutral sugar L-cladinose. The ability of these molecules and their L-cladinose counterparts to induce MLS(B) resistance in staphylococci (one strain) and streptococci (two strains) was investigated using a disc agar susceptibility method as well as measuring induction kinetics. All 14- and 15-membered ring macrolides tested showed inducing activity. In contrast, ketolides were clearly unable to induce MLS(B) resistance, a result consistent with the high in-vitro activity of this new class of antibiotics against erythromycin A-inducible resistant bacteria.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0305-7453
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
85-90
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9249208-Anti-Bacterial Agents,
pubmed-meshheading:9249208-Drug Resistance, Microbial,
pubmed-meshheading:9249208-Erythromycin,
pubmed-meshheading:9249208-Ketolides,
pubmed-meshheading:9249208-Kinetics,
pubmed-meshheading:9249208-Macrolides,
pubmed-meshheading:9249208-Microbial Sensitivity Tests,
pubmed-meshheading:9249208-Phenotype,
pubmed-meshheading:9249208-Staphylococcus aureus,
pubmed-meshheading:9249208-Streptococcus
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pubmed:year |
1997
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pubmed:articleTitle |
Ketolides lack inducibility properties of MLS(B) resistance phenotype.
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pubmed:affiliation |
Antiinfective Research Department, Roussel UCLAF, Romainville, France.
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pubmed:publicationType |
Journal Article,
Comparative Study
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