Linked Life Data

9248966

Source:http://linkedlifedata.com/resource/pubmed/id/9248966

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1997-9-8
pubmed:abstractText
Therapeutic monitoring is now technically feasible for a wide variety of antibiotic agents and data are accumulating on the relationship of blood levels and clinical efficacy. For each antibiotic a therapeutic range and dosage regimen can be based theoretically on its known pharmacokinetics, pharmacodynamics in vitro, and also use in animal and human treatment studies. Antibiotics can be characterised into types by their mechanism of kill, as either concentration-dependent (for which achieving a large post-dose concentration to MIC ratio appears important) or concentration-independent/time-dependent (where efficacy is related to maintain the overall concentration above the MIC). Hopefully, concentration-controlled trials will be performed when new antibiotics are introduced, to determine a therapeutic range which correlates with clinical efficacy, and so enable monitoring to lead to a more rational approach to antibiotic administration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1120-009X
pubmed:author
pubmed:issnType
Print
pubmed:volume
9 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
84-92
pubmed:dateRevised
2009-8-4
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Therapeutic monitoring, the concentration-effect relationship and impact on the clinical efficacy of antibiotic agents.
pubmed:affiliation
Trust Headquarters, Southmead Hospital, Westbury on Trym, Bristol, UK.
pubmed:publicationType
Journal Article, Review