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pubmed-article:9248749pubmed:abstractTextThe efficacy and safety of two different regimens for parenteral treatment of presumed severe febrile urinary tract infection were compared in a randomized study. One hundred fifty-eight patients were treated with either cefotaxime 2 g i.v. twice daily for at least two days followed by norfloxacin 400 mg twice daily orally or one bolus dose of gentamicin 3 mg/kg i.v. and norfloxacin from the start. Three patients randomized to cefotaxime died. Of the 101 patients with verified urinary tract infection, clinical response to assigned therapy was seen in 79% and 74%, respectively. There was no difference in fever duration between the two regimens. The results indicate that one bolus dose of gentamicin with early oral therapy is a safe and effective alternative to common parenteral regimens for empirical treatment of febrile urinary tract infection.lld:pubmed
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pubmed-article:9248749pubmed:dateRevised2005-11-17lld:pubmed
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pubmed-article:9248749pubmed:articleTitleOne bolus dose of gentamicin and early oral therapy versus cefotaxime and subsequent oral therapy in the treatment of febrile urinary tract infection.lld:pubmed
pubmed-article:9248749pubmed:affiliationDepartment of Infectious Diseases, Orebro Medical Center Hospital, Sweden.lld:pubmed
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