Linked Life Data

9246222

Source:http://linkedlifedata.com/resource/pubmed/id/9246222

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1997-9-5
pubmed:abstractText
The effects of the chronic administration of the sigma ligand JO 1784 (igmesine) CRF-induced changes in some behavioural, immune, endocrine and neurotransmitter parameters were studied. In the elevated plus maze, CRF (1.0 microgram i.c.v. daily x 5 days) induced a reduction in the number of entries and time spent on the open arms was significantly attenuated by the sigma ligand JO 1784 (3 mg/kg x 21 days) treatment. In the open field apparatus, the CRF-induced increase in the locomotor activity was also reduced by JO 1784 administration. JO 1784 treatment did not alter the concentration of the biogenic amine transmitters in the hypothalamus, nor reverse the increase in the turnover of serotonin and dopamine caused by CRF. JO 1784 treatment also failed to reverse a CRF-induced increase in the serum corticosterone, but it did reverse the reduction in phytohaemagglutinin and concanavalin A-induced lymphocyte proliferation caused by CRF but not the changes in the lymphocyte and neutrophil numbers caused by the peptide. These results demonstrate that JO 1784 has some antistress properties in CRF-treated rats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0302-282X
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
200-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Effect of chronic pretreatment with the sigma ligand JO 1784 on CRF-induced changes in behaviour, neurotransmitter and immunological function in the rat.
pubmed:affiliation
Life Sciences Research Centre, Carleton University, Ottawa, Ont., Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't