Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1997-8-28
pubmed:abstractText
Mouse and human macrophages express a plasma membrane receptor for extracellular ATP named P2Z/P2X7. This molecule, recently cloned, is endowed with the intriguing property of forming an aqueous pore that allows transmembrane fluxes of hydrophylic molecules of molecular weight below 900. The physiological function of this receptor is unknown. In a previous study we reported experiments suggesting that the P2Z/P2X7 receptor is involved in the formation of macrophage-derived multinucleated giant cells (MGCs; Falzoni, S., M. Munerati, D. Ferrari, S. Spisani, S. Moretti, and F. Di Virgilio. 1995. J. Clin. Invest. 95:1207- 1216). We have selected several clones of mouse J774 macrophages that are characterized by either high or low expression of the P2Z/P2X7 receptor and named these clones P2Zhyper or P2Zhypo, respectively. P2Zhyper, but not P2Zhypo, cells grown to confluence in culture spontaneously fuse to form MGCs. As previously shown for human macrophages, fusion is inhibited by the P2Z/P2X7 blocker oxidized ATP. MGCs die shortly after fusion through a dramatic process of cytoplasmic sepimentation followed by fragmentation. These observations support our previous hypothesis that the P2Z/P2X7 receptor is involved in macrophage fusion.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-1472003, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-17602, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-1918978, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-1976520, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-2136737, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-2206271, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-2291514, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-2291536, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-2789252, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-2950094, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-3258008, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-3392016, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-3597398, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-4404211, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-450099, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-481603, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-6162453, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-6431409, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-6481640, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-7495489, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-7514597, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-7519611, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-7523951, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-7523952, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-7530880, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-7538819, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-7541313, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-7541920, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-7544432, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-7678345, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-7883969, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-7919365, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-7931080, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-8299740, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-8454870, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-8463330, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-8573127, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-8596959, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-8614837, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-8650576, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-8685718, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-8791456, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-8879816, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-8879832, http://linkedlifedata.com/resource/pubmed/commentcorrection/9245796-9053458
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0021-9525
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
138
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
697-706
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1997
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