Linked Life Data

9243515

Source:http://linkedlifedata.com/resource/pubmed/id/9243515

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1997-9-29
pubmed:abstractText
The effect of alpha 2 adrenoceptor stimulation on neuropeptide Y (NPY) and NPYmRNA expression was studied in the rat cerebral cortex. For receptor stimulation clonidine was used in a dose of 50 micrograms/kg s.c., 3 times at every 8 h; brains were studied 30-40 min after the last dose using radioimmunoassay (RIA), immunocytochemistry and in situ hybridization methods. The RIA of NPY did not show any significant changes in the NPY immunoreactivity (IR) level in the whole cortex, whereas the immunohistochemical analysis demonstrated an increase in the number of NPY-IR neurons in ventral cortical regions, especially in external cortical layers. In situ hybridization histochemistry of NPYmRNA also performed in ventral cortical sections showed that clonidine increased NPY synthesis in some cortical neurons. The obtained results indicate that the alpha 2 adrenoceptor stimulation by clonidine increases the NPY content and synthesis in rat cortical neurons.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0143-4179
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
203-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Clonidine administration increases neuropeptide Y immunoreactivity and neuropeptide Y mRNA in the rat cerebral cortex neurons.
pubmed:affiliation
Department of Neurobiology, Polish Academy of Sciences, Kraków, Poland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't