| pubmed-article:9243326 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9243326 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:9243326 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:9243326 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9243326 | lifeskim:mentions | umls-concept:C0025465 | lld:lifeskim |
| pubmed-article:9243326 | lifeskim:mentions | umls-concept:C0001455 | lld:lifeskim |
| pubmed-article:9243326 | lifeskim:mentions | umls-concept:C0018338 | lld:lifeskim |
| pubmed-article:9243326 | lifeskim:mentions | umls-concept:C0288263 | lld:lifeskim |
| pubmed-article:9243326 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:9243326 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:9243326 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9243326 | pubmed:dateCreated | 1997-9-3 | lld:pubmed |
| pubmed-article:9243326 | pubmed:abstractText | L-type Ca2+ channel currents in cultured rat mesenteric artery smooth muscle cells were recorded by the cell-attached patch-clamp technique. Depolarizing voltage steps from a holding potential of -40 mV elicited voltage-dependent inward Ba2+ currents. The inward currents were inhibited by nifedipine (10 microM) but enhanced by Bay K 8644 (5 microM), which suggests that the inward currents are carried almost exclusively by L-type Ca2+ channels. Application of dibutyryl cAMP (0.1-1 microM) and forskolin (0.01-1 microM) enhanced the activity of these Ca2+ channels. The dibutyryl cAMP induced enhancement of Ca2+ channels was antagonized by the serine/threonine kinase inhibitor H-8 (1 microM). Application of 8-bromo-cGMP (0.01-1 microM) and the cGMP inducer nitroglycerin (0.01-1 microM) inhibited the activity of these Ca2+ channels, and the inhibition of channel activity induced by 8-bromo-cGMP was antagonized by the serine/threonine kinase inhibitor H-8 (1 microM). These results suggest that in rat mesenteric artery cells, the L-type Ca2+ channel current is enhanced by a rise in intracellular cAMP levels and suppressed by a rise in intracellular cGMP levels. Furthermore, cGMP-induced Ca2+ channel inhibition may play a role in the expression of the nitric oxide-mediated vasodilating action of drugs such as nitroglycerin and atrial natriuretic peptide. | lld:pubmed |
| pubmed-article:9243326 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9243326 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9243326 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9243326 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9243326 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9243326 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9243326 | pubmed:issn | 0021-5198 | lld:pubmed |
| pubmed-article:9243326 | pubmed:author | pubmed-author:UedaMM | lld:pubmed |
| pubmed-article:9243326 | pubmed:author | pubmed-author:KubaJJ | lld:pubmed |
| pubmed-article:9243326 | pubmed:author | pubmed-author:TaguchiKK | lld:pubmed |
| pubmed-article:9243326 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9243326 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:9243326 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9243326 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9243326 | pubmed:pagination | 179-86 | lld:pubmed |
| pubmed-article:9243326 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9243326 | pubmed:meshHeading | pubmed-meshheading:9243326-... | lld:pubmed |
| pubmed-article:9243326 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9243326 | pubmed:articleTitle | Effects of cAMP and cGMP on L-type calcium channel currents in rat mesenteric artery cells. | lld:pubmed |
| pubmed-article:9243326 | pubmed:affiliation | Department of Pharmacology, Showa College of Pharmaceutical Sciences, Tokyo, Japan. | lld:pubmed |
| pubmed-article:9243326 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9243326 | pubmed:publicationType | In Vitro | lld:pubmed |
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