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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1997-8-28
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pubmed:abstractText |
Apolipoprotein (apo) B100 mRNA undergoes site specific C to U editing, generating a stop-translation codon of apo B48 in the small intestine. This reaction is catalyzed in an editosome which contains APOBEC-1, a catalytic subunit. To clarify the functional significance of the apo B mRNA editing in lipoprotein metabolism, we have generated APOBEC-1 knockout mice and double knockout mice which are deficient in both APOBEC-1 and apo E. The apo B mRNA editing activity was markedly reduced and complete elimination of apo B48 from the plasma was observed in APOBEC-1(-/-) mice. Plasma triglyceride levels significantly increased in the double knockout mice (APOBEC-1(-/-);apo E(-/-)) as compared to apo E(-/-) mice. These results suggest that APOBEC-1(-/-) mice are a valuable model for experiments designed to understand a role of apo B mRNA editing.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0006-291X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
236
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
375-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9240444-Animals,
pubmed-meshheading:9240444-Apolipoprotein B-100,
pubmed-meshheading:9240444-Apolipoprotein B-48,
pubmed-meshheading:9240444-Apolipoproteins B,
pubmed-meshheading:9240444-Apolipoproteins E,
pubmed-meshheading:9240444-Cholesterol,
pubmed-meshheading:9240444-Cytidine Deaminase,
pubmed-meshheading:9240444-Lipids,
pubmed-meshheading:9240444-Mice,
pubmed-meshheading:9240444-Mice, Knockout,
pubmed-meshheading:9240444-RNA Editing
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pubmed:year |
1997
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|
pubmed:articleTitle |
Effects of apo E deficiency on plasma lipid levels in mice lacking APOBEC-1.
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pubmed:affiliation |
The Third Department of Internal Medicine, University of Tokyo, Bunkyo-ku, Japan.
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pubmed:publicationType |
Journal Article
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