| pubmed-article:9240391 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9240391 | lifeskim:mentions | umls-concept:C0124604 | lld:lifeskim |
| pubmed-article:9240391 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:9240391 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9240391 | lifeskim:mentions | umls-concept:C0946707 | lld:lifeskim |
| pubmed-article:9240391 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:9240391 | lifeskim:mentions | umls-concept:C0254837 | lld:lifeskim |
| pubmed-article:9240391 | lifeskim:mentions | umls-concept:C2004454 | lld:lifeskim |
| pubmed-article:9240391 | lifeskim:mentions | umls-concept:C0597879 | lld:lifeskim |
| pubmed-article:9240391 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:9240391 | lifeskim:mentions | umls-concept:C0597360 | lld:lifeskim |
| pubmed-article:9240391 | lifeskim:mentions | umls-concept:C0599668 | lld:lifeskim |
| pubmed-article:9240391 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:9240391 | pubmed:dateCreated | 1997-9-25 | lld:pubmed |
| pubmed-article:9240391 | pubmed:abstractText | Previous studies have suggested that target-derived nerve growth factor (NGF) is essential for the survival of cholinergic basal forebrain neurons. Thus, axotomy of septohippocampal neurons in adult rats resulting in the withdrawal of target-derived NGF caused a dramatic loss of choline acetyltransferase (ChAT)-immunoreactive neurons in the medial septum-diagonal band complex. We have recently shown that this loss of immunolabelled neurons does not indicate cell death, since many septohippocampal cholinergic neurons recover their immunoreactivity for ChAT after a long survival time despite disconnection from target-derived neurotrophins. One possibility would be that these surviving ChAT-immunoreactive neurons have gained access to other, probably local, NGF sources. Here we provide evidence that the recovery of ChAT immunoreactivity after axotomy is not accompanied by a similar recovery of NGF receptor expression in these neurons. In situ hybridization for p75NTR mRNA and trkA mRNA 6 months after bilateral fimbria-fornix transection revealed a substantial loss of labelled cells. In addition, there was a persisting loss of p75NTR-immunoreactive and NGF-immunoreactive medial septal neurons. Cholinergic neurons in controls did not express NGF mRNA, but were heavily immunostained for NGF protein due to receptor-mediated uptake. These data suggest that at least some cholinergic septohippocampal neurons re-express ChAT either independently of NGF or with a reduced need for NGF. | lld:pubmed |
| pubmed-article:9240391 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9240391 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9240391 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9240391 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9240391 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9240391 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9240391 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9240391 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9240391 | pubmed:issn | 0953-816X | lld:pubmed |
| pubmed-article:9240391 | pubmed:author | pubmed-author:FrotscherMM | lld:pubmed |
| pubmed-article:9240391 | pubmed:author | pubmed-author:NaumannTT | lld:pubmed |
| pubmed-article:9240391 | pubmed:author | pubmed-author:StraubeAA | lld:pubmed |
| pubmed-article:9240391 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9240391 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:9240391 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9240391 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9240391 | pubmed:pagination | 1340-9 | lld:pubmed |
| pubmed-article:9240391 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9240391 | pubmed:meshHeading | pubmed-meshheading:9240391-... | lld:pubmed |
| pubmed-article:9240391 | pubmed:meshHeading | pubmed-meshheading:9240391-... | lld:pubmed |
| pubmed-article:9240391 | pubmed:meshHeading | pubmed-meshheading:9240391-... | lld:pubmed |
| pubmed-article:9240391 | pubmed:meshHeading | pubmed-meshheading:9240391-... | lld:pubmed |
| pubmed-article:9240391 | pubmed:meshHeading | pubmed-meshheading:9240391-... | lld:pubmed |
| pubmed-article:9240391 | pubmed:meshHeading | pubmed-meshheading:9240391-... | lld:pubmed |
| pubmed-article:9240391 | pubmed:meshHeading | pubmed-meshheading:9240391-... | lld:pubmed |
| pubmed-article:9240391 | pubmed:meshHeading | pubmed-meshheading:9240391-... | lld:pubmed |
| pubmed-article:9240391 | pubmed:meshHeading | pubmed-meshheading:9240391-... | lld:pubmed |
| pubmed-article:9240391 | pubmed:meshHeading | pubmed-meshheading:9240391-... | lld:pubmed |
| pubmed-article:9240391 | pubmed:meshHeading | pubmed-meshheading:9240391-... | lld:pubmed |
| pubmed-article:9240391 | pubmed:meshHeading | pubmed-meshheading:9240391-... | lld:pubmed |
| pubmed-article:9240391 | pubmed:meshHeading | pubmed-meshheading:9240391-... | lld:pubmed |
| pubmed-article:9240391 | pubmed:meshHeading | pubmed-meshheading:9240391-... | lld:pubmed |
| pubmed-article:9240391 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9240391 | pubmed:articleTitle | Recovery of ChAT immunoreactivity in axotomized rat cholinergic septal neurons despite reduced NGF receptor expression. | lld:pubmed |
| pubmed-article:9240391 | pubmed:affiliation | Institute of Anatomy, University of Freiburg, Germany. | lld:pubmed |
| pubmed-article:9240391 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9240391 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9240391 | lld:pubmed |
