Linked Life Data

9239452

Source:http://linkedlifedata.com/resource/pubmed/id/9239452

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1997-9-4
pubmed:abstractText
The absorption, distribution, metabolism, and excretion of miglitol ((2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)-3,4,5-piperidinet riol, CAS 72432-03-2, BAY m 1099) have been studied following single and repeated administration of non-labelled and radiolabelled (3H, 14C) drug to rats, dogs, and human volunteers via different routes of administration (intravenous, oral, intraduodenal) and at various doses (0.3-450 mg/kg). After intravenous administration, miglitol is excreted rapidly and completely via the renal route. No indication was found for a metabolization of radiolabelled miglitol. The (renal) clearance of miglitol is in the range of the glomerular filtration rate. Miglitol is rapidly eliminated from plasma with apparent elimination half-lives of 0.4-1.8 h. Miglitol is virtually not bound to plasma proteins. After oral administration miglitol is rapidly and at low doses also completely absorbed. At higher doses (> or = 5 mg/kg in rats and dogs, > 50 mg in humans) a saturation of absorption becomes evident. Miglitol is distributed predominantly in the extracellular space. The volumes of distribution are low (0.3-0.8 l/ kg). In rats high concentrations were initially found in the kidneys, the blood and some well-perfused tissues. The permeation across the blood/brain barrier is very low. Elimination from organs and tissues occurs rapidly resulting in very low residual radioactivity in the body 2 days after dosing (< 0.9% of the dose). At this very low concentration level a terminal elimination phase of radioactivity characterized by half-lives of 50-110 h was observed giving rise to a slight tendency for accumulation (accumulation factors < 6) following repeated administration to rats. In pregnant rats [14C]miglitol crossed the placental barrier slowly and to a limited extent. In lactating rats miglitol was found in milk in concentrations similar to those in the maternal plasma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
734-45
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:9239452-1-Deoxynojirimycin, pubmed-meshheading:9239452-Administration, Oral, pubmed-meshheading:9239452-Animals, pubmed-meshheading:9239452-Autoradiography, pubmed-meshheading:9239452-Blood Proteins, pubmed-meshheading:9239452-Dogs, pubmed-meshheading:9239452-Duodenum, pubmed-meshheading:9239452-Enzyme Inhibitors, pubmed-meshheading:9239452-Feces, pubmed-meshheading:9239452-Female, pubmed-meshheading:9239452-Glucosamine, pubmed-meshheading:9239452-Humans, pubmed-meshheading:9239452-Imino Pyranoses, pubmed-meshheading:9239452-Injections, Intravenous, pubmed-meshheading:9239452-Male, pubmed-meshheading:9239452-Milk, pubmed-meshheading:9239452-Placenta, pubmed-meshheading:9239452-Pregnancy, pubmed-meshheading:9239452-Protein Binding, pubmed-meshheading:9239452-Rats, pubmed-meshheading:9239452-Rats, Sprague-Dawley, pubmed-meshheading:9239452-Rats, Wistar, pubmed-meshheading:9239452-Species Specificity, pubmed-meshheading:9239452-Tissue Distribution, pubmed-meshheading:9239452-alpha-Glucosidases
pubmed:year
1997
pubmed:articleTitle
Pharmacokinetics of miglitol. Absorption, distribution, metabolism, and excretion following administration to rats, dogs, and man.
pubmed:affiliation
Bayer AG, Wuppertal, Germany.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Controlled Clinical Trial