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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1997-8-25
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pubmed:databankReference |
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pubmed:abstractText |
GB virus C/hepatitis G virus (GBV-C/HGV) is a newly described virus associated with hepatitis in humans, and GBV-C/HGV coinfection is common in patients chronically infected with hepatitis C virus (HCV). To determine the clinical impact of GBV-C/HGV infection in such patients and the effect of interferon-alpha and ribavirin therapy on serum GBV-C/HGV RNA levels, GBV-C/HGV RNA was detected and quantitated in serum samples from 62 chronically infected HCV patients by a combination of a qualitative nested reverse transcription-polymerase chain reaction and a newly developed quantitative branched DNA assay: 10 patients were positive for serum GBV-C/HGV RNA. There were no differences in the clinical, biochemical, and histologic features of the patients with GBV-C/HGV-HCV coinfection compared with those with HCV infection alone. Interferon-alpha treatment caused a marked but usually transient reduction in serum GBV-C/HGV RNA, and ribavirin had, at most, a modest antiviral effect.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-1899
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
176
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
421-6
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:9237707-Adult,
pubmed-meshheading:9237707-Alanine Transaminase,
pubmed-meshheading:9237707-Antiviral Agents,
pubmed-meshheading:9237707-Chronic Disease,
pubmed-meshheading:9237707-DNA, Viral,
pubmed-meshheading:9237707-Drug Therapy, Combination,
pubmed-meshheading:9237707-Female,
pubmed-meshheading:9237707-Flaviviridae,
pubmed-meshheading:9237707-Genetic Techniques,
pubmed-meshheading:9237707-Hepatitis, Viral, Human,
pubmed-meshheading:9237707-Hepatitis C,
pubmed-meshheading:9237707-Humans,
pubmed-meshheading:9237707-Interferon Type I,
pubmed-meshheading:9237707-Liver,
pubmed-meshheading:9237707-Male,
pubmed-meshheading:9237707-Middle Aged,
pubmed-meshheading:9237707-Molecular Sequence Data,
pubmed-meshheading:9237707-Phylogeny,
pubmed-meshheading:9237707-Polymerase Chain Reaction,
pubmed-meshheading:9237707-RNA, Viral,
pubmed-meshheading:9237707-Recombinant Proteins,
pubmed-meshheading:9237707-Ribavirin,
pubmed-meshheading:9237707-Sensitivity and Specificity,
pubmed-meshheading:9237707-Sequence Analysis, DNA,
pubmed-meshheading:9237707-Viremia
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pubmed:year |
1997
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pubmed:articleTitle |
Effect of interferon-alpha and ribavirin therapy on serum GB virus C/hepatitis G virus (GBV-C/HGV) RNA levels in patients chronically infected with hepatitis C virus and GBV-C/HGV.
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pubmed:affiliation |
Department of Medicine, University of Florida, Gainesville 32610, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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