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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2-3
|
| pubmed:dateCreated |
1997-9-3
|
| pubmed:abstractText |
We have investigated the expression of neuronal-type NO synthase I (NOS I) and inducible-type NOS II in guinea pig skeletal muscle (diaphragm). Expression of NOS I mRNA and protein was highest in muscle of specific pathogen-free animals, lower in normally bred animals, and lowest in lipopolysaccharide (LPS)-treated animals. NOS II mRNA and protein levels were highest in muscle of LPS-treated animals. Elevated NOS activity in muscle from LPS-treated animals was less susceptible to the NOS I-selective inhibitor N(G)-nitro-L-arginine. Expressional downregulation of NOS I in sepsis may have implications for contractile function of skeletal muscle.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0014-5793
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
30
|
| pubmed:volume |
410
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
319-23
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9237654-Animals,
pubmed-meshheading:9237654-Down-Regulation,
pubmed-meshheading:9237654-Guinea Pigs,
pubmed-meshheading:9237654-Lipopolysaccharides,
pubmed-meshheading:9237654-Male,
pubmed-meshheading:9237654-Muscle, Skeletal,
pubmed-meshheading:9237654-Neurons,
pubmed-meshheading:9237654-Nitric Oxide Synthase
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Expressional downregulation of neuronal-type NO synthase I in guinea pig skeletal muscle in response to bacterial lipopolysaccharide.
|
| pubmed:affiliation |
Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany. gath@mzdmza.zdv.uni-mainz.de
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|