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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1997-9-23
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pubmed:abstractText |
A new linker that employs a photosensitive 3-amino-3-(2-nitrophenyl)propionyl functionality (ANP-resin) has been developed for the preparation of C-terminal carboxamides. A wide range of carboxamides were prepared and identified using the ANP-resin and electrospray ionization mass spectrometry. A single bead containing tripeptide Fmoc-Asp-Arg(Tos)-Val-NH2 was isolated, photocleaved and the peptide was characterized by tandem mass spectrometry, thereby verifying a library decode strategy that avoids complex tagging procedures.
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pubmed:language |
eng
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:author |
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4-12
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9237189-Amino Acid Sequence,
pubmed-meshheading:9237189-Cross-Linking Reagents,
pubmed-meshheading:9237189-Directed Molecular Evolution,
pubmed-meshheading:9237189-Drug Design,
pubmed-meshheading:9237189-Mass Spectrometry,
pubmed-meshheading:9237189-Molecular Structure,
pubmed-meshheading:9237189-Oligopeptides,
pubmed-meshheading:9237189-Peptide Library,
pubmed-meshheading:9237189-Photochemistry,
pubmed-meshheading:9237189-Propionic Acids,
pubmed-meshheading:9237189-Resins, Synthetic
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pubmed:articleTitle |
A single-bead decode strategy using electrospray ionization mass spectrometry and a new photolabile linker: 3-amino-3-(2-nitrophenyl)propionic acid.
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pubmed:affiliation |
Diversity Sciences Department, Glaxo Wellcome Inc., Research Triangle Park, NC 27709, USA.
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pubmed:publicationType |
Journal Article
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