Linked Life Data

9236973

Source:http://linkedlifedata.com/resource/pubmed/id/9236973

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1997-8-26
pubmed:abstractText
The development of artificial blood requires the understanding of how blood behaves at the level of the microcirculation. A number of measuring systems have recently become available that allow analysis of the transport properties of blood and the microvessels in terms of pressure, flow, the dynamics of their diameter changes, and the rate and manner of oxygen delivery. Findings from this technology have led to the development of an analytical framework with which to assess the consequences of altering the physical properties of blood and to verify quantitatively theoretical predictions. Results show that blood viscosity and oxygen-carrying capacity are directly related, and must be jointly modified in a prescribed manner to maintain tissue oxygen delivery. The use of optical techniques to assess flow and oxygen delivery in experimental animal models show that the consumption of oxygen by the microvessel wall is an important determinant of tissue oxygenation. Furthermore, the viscosity of blood and/or the mixture of blood and an artificial substitute must achieve a viscosity that is close to normal. Low blood viscosity is not necessarily beneficial, unless blood flow velocity rises to maintain the shear stress at the wall needed for the generation of local vasodilators. Manipulating physical properties of currently available modified hemoglobins by mixing them with conventional plasma expanders yield fluids that may provide optimal blood replacements.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0090-6964
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
593-603
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Whitaker Lecture 1996: microcirculation, biomedical engineering, and artificial blood.
pubmed:affiliation
Department of Bioengineering, University of California-San Diego, La Jolla 92093-0412, USA.
pubmed:publicationType
Research Support, U.S. Gov't, P.H.S., Lectures