Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1997-8-14
pubmed:abstractText
We assessed the capacity of four probiotic bacteria (Lactobacillus acidophilus, Lactobacillus reuteri, Lactobacillus casei GG, and Bifidobacterium animalis) to colonize, infect, stimulate immune responses in, and affect the growth and survival of congenitally immunodeficient gnotobiotic beige-athymic (bg/bg-nu/nu) and beige-euthymic (bg/bg-nu/+) mice. The bacteria colonized and persisted, in pure culture, in the alimentary tracts of both mouse strains for the entire study period (12 weeks). Although all adult and neonatal beige-euthymic mice survived probiotic colonization, some infant mortality occurred in beige-athymic pups born to mothers colonized with pure cultures of L. reuteri or L. casei GG. The probiotic bacteria manifested different capacities to adhere to epithelial surfaces, disseminate to internal organs, affect the body weight of adult mice and the growth of neonatal mice, and stimulate immune responses. Although the probiotic species were innocuous for adults, these results suggest that caution and further studies to assess the safety of probiotic bacteria for immunodeficient hosts, especially neonates, are required.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9234796-1447056, http://linkedlifedata.com/resource/pubmed/commentcorrection/9234796-1530285, http://linkedlifedata.com/resource/pubmed/commentcorrection/9234796-154474, http://linkedlifedata.com/resource/pubmed/commentcorrection/9234796-1586251, http://linkedlifedata.com/resource/pubmed/commentcorrection/9234796-1722492, http://linkedlifedata.com/resource/pubmed/commentcorrection/9234796-1728822, http://linkedlifedata.com/resource/pubmed/commentcorrection/9234796-1736766, http://linkedlifedata.com/resource/pubmed/commentcorrection/9234796-1860970, http://linkedlifedata.com/resource/pubmed/commentcorrection/9234796-2224835, http://linkedlifedata.com/resource/pubmed/commentcorrection/9234796-7558298, http://linkedlifedata.com/resource/pubmed/commentcorrection/9234796-7593855, http://linkedlifedata.com/resource/pubmed/commentcorrection/9234796-7622883, http://linkedlifedata.com/resource/pubmed/commentcorrection/9234796-7698950, http://linkedlifedata.com/resource/pubmed/commentcorrection/9234796-7876463, http://linkedlifedata.com/resource/pubmed/commentcorrection/9234796-7932620, http://linkedlifedata.com/resource/pubmed/commentcorrection/9234796-7934445, http://linkedlifedata.com/resource/pubmed/commentcorrection/9234796-7936821, http://linkedlifedata.com/resource/pubmed/commentcorrection/9234796-8228371, http://linkedlifedata.com/resource/pubmed/commentcorrection/9234796-8439162, http://linkedlifedata.com/resource/pubmed/commentcorrection/9234796-8468264, http://linkedlifedata.com/resource/pubmed/commentcorrection/9234796-8513050, http://linkedlifedata.com/resource/pubmed/commentcorrection/9234796-8525967, http://linkedlifedata.com/resource/pubmed/commentcorrection/9234796-8525971, http://linkedlifedata.com/resource/pubmed/commentcorrection/9234796-8579995, http://linkedlifedata.com/resource/pubmed/commentcorrection/9234796-8599881, http://linkedlifedata.com/resource/pubmed/commentcorrection/9234796-8769618, http://linkedlifedata.com/resource/pubmed/commentcorrection/9234796-8852980, http://linkedlifedata.com/resource/pubmed/commentcorrection/9234796-8934676
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3345-51
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Colonization of congenitally immunodeficient mice with probiotic bacteria.
pubmed:affiliation
Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison 53706-1532, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't