Linked Life Data

9234773

Source:http://linkedlifedata.com/resource/pubmed/id/9234773

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:9234773rdf:typepubmed:Citationlld:pubmed
pubmed-article:9234773lifeskim:mentionsumls-concept:C0036111lld:lifeskim
pubmed-article:9234773lifeskim:mentionsumls-concept:C0036536lld:lifeskim
pubmed-article:9234773lifeskim:mentionsumls-concept:C0123759lld:lifeskim
pubmed-article:9234773lifeskim:mentionsumls-concept:C0036537lld:lifeskim
pubmed-article:9234773lifeskim:mentionsumls-concept:C0024432lld:lifeskim
pubmed-article:9234773lifeskim:mentionsumls-concept:C0033684lld:lifeskim
pubmed-article:9234773lifeskim:mentionsumls-concept:C0178719lld:lifeskim
pubmed-article:9234773lifeskim:mentionsumls-concept:C0547040lld:lifeskim
pubmed-article:9234773lifeskim:mentionsumls-concept:C0205263lld:lifeskim
pubmed-article:9234773lifeskim:mentionsumls-concept:C1711351lld:lifeskim
pubmed-article:9234773lifeskim:mentionsumls-concept:C0591833lld:lifeskim
pubmed-article:9234773pubmed:issue8lld:pubmed
pubmed-article:9234773pubmed:dateCreated1997-8-14lld:pubmed
pubmed-article:9234773pubmed:abstractTextThe induction by intracellular pathogens of interleukin-12 (IL-12) secretion is of particular importance since this cytokine has been shown to be necessary for optimal cell-mediated immune responses. Several recent investigations have suggested that cultured macrophages are a significant source of IL-12 following intracellular infection with pathogens such as Salmonella spp. In an effort to critically evaluate the magnitude of the IL-12 response in cultured macrophages following interaction with Salmonella dublin, enzyme-linked immunosorbent assays specific for the 40- and 70-kDa subunits of IL-12 (IL-12p40 and IL-12p70) and a sensitive bioassay for IL-12p70 were used. Using BALB/c macrophages, S. dublin at various challenge doses was a potent inducer of IL-12p40 secretion (>6,000 pg/10(7) macrophages). However when secretion of IL-12p70 was evaluated, S. dublin did not induce comparable IL-12p70 production (<80 pg/10(7) macrophages) at any time, despite varying the challenge dose of Salmonella. The limited ability of BALB/c (Ity(s)) macrophages to secrete IL-12p70 in response to Salmonella was not a strain-specific phenomenon since similar results were demonstrated for macrophages isolated from CBA/J (Ity(r)) and C3H/HeJ (lipopolysaccharide [LPS]-hyporesponsive) mice. While intracellular infection with Salmonella was not a potent stimulus for IL-12p70 secretion in these mouse strains, macrophages from these mice responded significantly to a stimulus of gamma interferon plus LPS. Taken together these results demonstrate a limited capacity for intracellular Salmonella to stimulate murine macrophage secretion of IL-12p70, despite being a significant stimulus for IL-12p40 secretion. Furthermore, our results suggest that Salmonella-induced IL-12p40 secretion by macrophages is not solely an LPS-mediated event.lld:pubmed
pubmed-article:9234773pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:languageenglld:pubmed
pubmed-article:9234773pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:citationSubsetIMlld:pubmed
pubmed-article:9234773pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9234773pubmed:statusMEDLINElld:pubmed
pubmed-article:9234773pubmed:monthAuglld:pubmed
pubmed-article:9234773pubmed:issn0019-9567lld:pubmed
pubmed-article:9234773pubmed:authorpubmed-author:ClementsJ DJDlld:pubmed
pubmed-article:9234773pubmed:authorpubmed-author:BostK LKLlld:pubmed
pubmed-article:9234773pubmed:issnTypePrintlld:pubmed
pubmed-article:9234773pubmed:volume65lld:pubmed
pubmed-article:9234773pubmed:ownerNLMlld:pubmed
pubmed-article:9234773pubmed:authorsCompleteYlld:pubmed
pubmed-article:9234773pubmed:pagination3186-92lld:pubmed
pubmed-article:9234773pubmed:dateRevised2009-11-18lld:pubmed
pubmed-article:9234773pubmed:meshHeadingpubmed-meshheading:9234773-...lld:pubmed
pubmed-article:9234773pubmed:meshHeadingpubmed-meshheading:9234773-...lld:pubmed
pubmed-article:9234773pubmed:meshHeadingpubmed-meshheading:9234773-...lld:pubmed
pubmed-article:9234773pubmed:meshHeadingpubmed-meshheading:9234773-...lld:pubmed
pubmed-article:9234773pubmed:meshHeadingpubmed-meshheading:9234773-...lld:pubmed
pubmed-article:9234773pubmed:meshHeadingpubmed-meshheading:9234773-...lld:pubmed
pubmed-article:9234773pubmed:meshHeadingpubmed-meshheading:9234773-...lld:pubmed
pubmed-article:9234773pubmed:meshHeadingpubmed-meshheading:9234773-...lld:pubmed
pubmed-article:9234773pubmed:meshHeadingpubmed-meshheading:9234773-...lld:pubmed
pubmed-article:9234773pubmed:meshHeadingpubmed-meshheading:9234773-...lld:pubmed
pubmed-article:9234773pubmed:meshHeadingpubmed-meshheading:9234773-...lld:pubmed
pubmed-article:9234773pubmed:year1997lld:pubmed
pubmed-article:9234773pubmed:articleTitleIntracellular Salmonella dublin induces substantial secretion of the 40-kilodalton subunit of interleukin-12 (IL-12) but minimal secretion of IL-12 as a 70-kilodalton protein in murine macrophages.lld:pubmed
pubmed-article:9234773pubmed:affiliationDepartment of Microbiology and Immunology, Tulane University Medical Center, New Orleans, Louisiana 70112, USA. kbost@tmcpop.tmc.tulane.edulld:pubmed
pubmed-article:9234773pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9234773pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9234773lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9234773lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9234773lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9234773lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9234773lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9234773lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9234773lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9234773lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9234773lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9234773lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:9234773lld:pubmed
More...