Linked Life Data

9234252

Source:http://linkedlifedata.com/resource/pubmed/id/9234252

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1997-9-8
pubmed:abstractText
In the present investigation, we examined cerebral blood flow (CBF), numerical density of oligodendroglia and extent of white matter lesions after bilateral ligation of common carotid arteries in Wistar rats. Doppler flow-meter revealed a reduction of CBF to 30-40% of that before operation after 1 and 3 days, however recovered to 50-60% after 7 and 14 days. Semiquantitative evaluation with immunohistochemistry for transferrin showed a numerical decrease of oligodendroglia in the medial corpus callosum after 14 and 30 days. Tissue rare-faction promptly occurred in the optic nerve and optic tract after 3 days, whereas it was delayed to 7 days after operation and increased in intensity gradually in the other white matter regions. These results indicate that bilateral occlusion of common carotid arteries in Wistar rats elicits a chronic cerebral hypoperfusion, which cumulatively leads to delayed appearance of white matter lesions.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-8969
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
639-44
pubmed:dateRevised
2007-2-22
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
[White matter lesions after occlusion of the bilateral carotid arteries in the rat--temporal profile of cerebral blood flow (CBF), oligodendroglia and myelin].
pubmed:affiliation
Department of Neurology, Faculty of Medicine, Kyoto University, Japan.
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't