Linked Life Data

9230448

Source:http://linkedlifedata.com/resource/pubmed/id/9230448

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-8-12
pubmed:abstractText
The possible adjuvant effect of diesel exhaust particles (DEP) on the response to the model allergen ovalbumin (OA) was studied in BALB/c mice using the popliteal lymph node (PLN) assay. In addition to changes in PLN weight, cell numbers and cell proliferation, specific serum IgE anti-OA antibody levels were measured. OA inoculated together with DEP into one hind footpad gave a significantly augmented response (increase in weight, cell numbers and cell proliferation) in the draining popliteal lymph node as compared to DEP or OA alone. Also, the local lymph node response was of longer duration when DEP were given with the allergen. Experiments in thymus-deficient nu/nu mice indicated that the lymph node response observed in BALB/c mice was of a specific immunologic character and not an unspecific inflammatory reaction. The OA-specific IgE response was increased in mice receiving OA together with DEP as compared to the response in mice receiving OA without DEP. Carbon black (CB) was given with and without OA in some experiments, as a surrogate for the non-extractable core of DEP. CB was found to resemble DEP in its capacity to increase the local lymph node response and serum specific IgE response to OA, but CB appeared to be slightly less potent than DEP. Thus, both DEP and CB had a significant adjuvant effect on the local immune-mediated inflammatory response and on the systemic specific IgE response to allergen. The results indicate that the non-extractable particle core contributes substantially to the adjuvant activity of DEP.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0300-483X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
121
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
165-78
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9230448-Adjuvants, Immunologic, pubmed-meshheading:9230448-Analysis of Variance, pubmed-meshheading:9230448-Animals, pubmed-meshheading:9230448-Carbon, pubmed-meshheading:9230448-Cell Division, pubmed-meshheading:9230448-Disease Models, Animal, pubmed-meshheading:9230448-Drug Synergism, pubmed-meshheading:9230448-Female, pubmed-meshheading:9230448-Hindlimb, pubmed-meshheading:9230448-Immunoglobulin E, pubmed-meshheading:9230448-Immunoglobulin G, pubmed-meshheading:9230448-Leukocyte Count, pubmed-meshheading:9230448-Lymph Nodes, pubmed-meshheading:9230448-Lymphadenitis, pubmed-meshheading:9230448-Mice, pubmed-meshheading:9230448-Mice, Inbred BALB C, pubmed-meshheading:9230448-Mice, Nude, pubmed-meshheading:9230448-Organ Size, pubmed-meshheading:9230448-Ovalbumin, pubmed-meshheading:9230448-Particle Size, pubmed-meshheading:9230448-Random Allocation, pubmed-meshheading:9230448-Specific Pathogen-Free Organisms, pubmed-meshheading:9230448-Vehicle Emissions
pubmed:year
1997
pubmed:articleTitle
Diesel exhaust particles and carbon black have adjuvant activity on the local lymph node response and systemic IgE production to ovalbumin.
pubmed:affiliation
Department of Environmental Medicine, National Institute of Public Health, Oslo, Norway.
pubmed:publicationType
Journal Article, Comparative Study