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rdf:type |
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lifeskim:mentions |
umls-concept:C0007589,
umls-concept:C0033684,
umls-concept:C0040648,
umls-concept:C0080347,
umls-concept:C0178555,
umls-concept:C0450030,
umls-concept:C0521432,
umls-concept:C1333663,
umls-concept:C1426391,
umls-concept:C1511938,
umls-concept:C1516960,
umls-concept:C1530719,
umls-concept:C1551336
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pubmed:issue |
1
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pubmed:dateCreated |
1997-8-26
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pubmed:databankReference |
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pubmed:abstractText |
The hematopoietic transcription factor GATA-1 is essential for development of the erythroid and megakaryocytic lineages. Using the conserved zinc finger DNA-binding domain of GATA-1 in the yeast two-hybrid system, we have identified a novel, multitype zinc finger protein, Friend of GATA-1 (FOG), which binds GATA-1 but not a functionally inactive mutant lacking the amino (N) finger. FOG is coexpressed with GATA-1 during embryonic development and in erythroid and megakaryocytic cells. Furthermore, FOG and GATA-1 synergistically activate transcription from a hematopoietic-specific regulatory region and cooperate during both erythroid and megakaryocytic cell differentiation. These findings indicate that FOG acts as a cofactor for GATA-1 and provide a paradigm for the regulation of cell type-specific gene expression by GATA transcription factors.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
109-19
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9230307-3T3 Cells,
pubmed-meshheading:9230307-Amino Acid Sequence,
pubmed-meshheading:9230307-Animals,
pubmed-meshheading:9230307-Binding Sites,
pubmed-meshheading:9230307-Carrier Proteins,
pubmed-meshheading:9230307-Cell Differentiation,
pubmed-meshheading:9230307-Cloning, Molecular,
pubmed-meshheading:9230307-Conserved Sequence,
pubmed-meshheading:9230307-DNA-Binding Proteins,
pubmed-meshheading:9230307-Embryo, Mammalian,
pubmed-meshheading:9230307-Embryonic and Fetal Development,
pubmed-meshheading:9230307-Erythroid Precursor Cells,
pubmed-meshheading:9230307-Erythroid-Specific DNA-Binding Factors,
pubmed-meshheading:9230307-GATA1 Transcription Factor,
pubmed-meshheading:9230307-Gene Expression Regulation, Developmental,
pubmed-meshheading:9230307-Hematopoiesis,
pubmed-meshheading:9230307-Megakaryocytes,
pubmed-meshheading:9230307-Mice,
pubmed-meshheading:9230307-Molecular Sequence Data,
pubmed-meshheading:9230307-Mutagenesis, Site-Directed,
pubmed-meshheading:9230307-Nuclear Proteins,
pubmed-meshheading:9230307-Polymerase Chain Reaction,
pubmed-meshheading:9230307-Recombinant Fusion Proteins,
pubmed-meshheading:9230307-Saccharomyces cerevisiae,
pubmed-meshheading:9230307-Transcription Factors,
pubmed-meshheading:9230307-Transcriptional Activation,
pubmed-meshheading:9230307-Transfection,
pubmed-meshheading:9230307-Zinc Fingers
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pubmed:year |
1997
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pubmed:articleTitle |
FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation.
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pubmed:affiliation |
Children's Hospital and Dana-Farber Cancer Institute, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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