Linked Life Data

9226591

Source:http://linkedlifedata.com/resource/pubmed/id/9226591

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9-10
pubmed:dateCreated
1997-9-16
pubmed:abstractText
The pharmacokinetic interaction of oral rifampicin (1200 mg) and oral nifedipine (10 mg capsules), given as single doses, was investigated in six healthy volunteers (mean age 28.5 +/- 6.3 years and mean weight 67.0 +/- 4/45 kg). The plasma concentrations of nifedipine was monitored using a HPLC technique, 8 h after pre-treatment, with rifampicin. The mean relative bioavailability of nifedipine following pre-treatment with rifampicin 1200 mg was 35.8% (P < 0.0001). The mean elimination half life (t1/2) of nifedipine decreased from 2.62 to 1.03 h (P < 0.0001); and, the total clearance (ClT) increased from 17.33 to 50.17 ml min-1 kg-1 (P < 0.0001). There were no significant differences in Vd and Tmax. The study suggests that the effect of induction by rifampicin decreases the bioavailability of nifedipine by either increasing the first pass effect or decreasing its oral absorption. The induction also increases the clearance of nifedipine.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0731-7085
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1571-5
pubmed:dateRevised
2009-11-3
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
The effect of single does of rifampicin on the pharmacokinetics of oral nifedipine.
pubmed:affiliation
Department of Pharmaceutical and Medicinal Chemistry, Ahmadu Bello University, Zaria, Nigeria.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't