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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1997-8-14
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pubmed:abstractText |
Quantitative and qualitative assessment of the clinical disease manifestations in 41 primary Sjögren's syndrome (pSS) patients was performed according to a new classification model. Frequencies of subgrouped disease manifestations were as follows: 1) surface exocrine disease: 100%, 2) internal organ exocrine disease: 63%, 3) monoclonal B lymphocyte disease: 5%, 4) inflammatory vascular disease: 71%, 5) non-inflammatory vascular disease: 59%, 6) mediator induced disease: 98%. Summary scores for severity of surface exocrine disease correlated to the summary scores of all other disease manifestations (p = 0.02), to the summary scores of internal organ exocrine disease (p = 0.003), and to the summary scores of mediator induced disease (p = 0.03). Blood leucocyte counts showed significant negative correlations to levels of plasma IgG, serum IgA-RF, IgM-RF, anti-SSA/SSB antibodies, IL-6, and IL-1Ra. We conclude that the model made detailed analysis of the clinical presentation of pSS possible, and thus may assist in elucidating important pathobiological aspect of the disease.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0300-9742
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
197-205
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9225875-Adult,
pubmed-meshheading:9225875-Aged,
pubmed-meshheading:9225875-Aged, 80 and over,
pubmed-meshheading:9225875-Autoantibodies,
pubmed-meshheading:9225875-Blood Proteins,
pubmed-meshheading:9225875-Cross-Sectional Studies,
pubmed-meshheading:9225875-Cytokines,
pubmed-meshheading:9225875-Female,
pubmed-meshheading:9225875-Humans,
pubmed-meshheading:9225875-Immune System,
pubmed-meshheading:9225875-Interleukins,
pubmed-meshheading:9225875-Male,
pubmed-meshheading:9225875-Middle Aged,
pubmed-meshheading:9225875-Severity of Illness Index,
pubmed-meshheading:9225875-Sjogren's Syndrome
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pubmed:year |
1997
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pubmed:articleTitle |
Quantitative assessment of clinical disease status in primary Sjögren's syndrome. A cross-sectional study using a new classification model.
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pubmed:affiliation |
Department of Medicine TA, Rigshospitalet, Copenhagen, Denmark.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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