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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1997-8-7
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pubmed:abstractText |
Borna disease virus (BDV) infects astrocytes in the Lewis rat brain. BDV-infected astrocytes have been shown to express MHC class II in vitro but not in vivo. Using a sensitive fluorescence-activated cytometric technique, we now report the detection of MHC class II on freshly harvested S100-positive cells from BDV-infected rat brain, without an intervening in vitro culture step. These data support the hypothesis that astrocytes from BDV-infected rats express MHC class II on their surface and, thus, are potential participants in the encephalitic response to BDV infection.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0014-4886
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
146
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
286-90
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9225763-Animals,
pubmed-meshheading:9225763-Astrocytes,
pubmed-meshheading:9225763-Borna Disease,
pubmed-meshheading:9225763-Borna disease virus,
pubmed-meshheading:9225763-Brain,
pubmed-meshheading:9225763-Encephalitis, Viral,
pubmed-meshheading:9225763-Flow Cytometry,
pubmed-meshheading:9225763-Histocompatibility Antigens Class II,
pubmed-meshheading:9225763-Immunohistochemistry,
pubmed-meshheading:9225763-Rats,
pubmed-meshheading:9225763-S100 Proteins,
pubmed-meshheading:9225763-Sensitivity and Specificity
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pubmed:year |
1997
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pubmed:articleTitle |
Flow cytometric analysis of major histocompatibility complex (MHC) class II antigen expression on brain cells from Borna disease virus-infected rats without an intervening in vitro culture step.
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pubmed:affiliation |
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21218, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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