| pubmed-article:9224837 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9224837 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:9224837 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9224837 | lifeskim:mentions | umls-concept:C0039729 | lld:lifeskim |
| pubmed-article:9224837 | lifeskim:mentions | umls-concept:C0205098 | lld:lifeskim |
| pubmed-article:9224837 | lifeskim:mentions | umls-concept:C0220839 | lld:lifeskim |
| pubmed-article:9224837 | lifeskim:mentions | umls-concept:C0085845 | lld:lifeskim |
| pubmed-article:9224837 | lifeskim:mentions | umls-concept:C1441616 | lld:lifeskim |
| pubmed-article:9224837 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:9224837 | lifeskim:mentions | umls-concept:C0054444 | lld:lifeskim |
| pubmed-article:9224837 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9224837 | pubmed:dateCreated | 1997-9-12 | lld:pubmed |
| pubmed-article:9224837 | pubmed:abstractText | Topographical and quantitative features of medial thalamic neurons in which aspartate (ASP) or glutamate (GLU) might act as neurotransmitters were investigated in the rat. The calcium-binding protein calbindin D-28k (CB) was exploited as a marker of neuronal subsets, thus allowing us to study also the relationships between the CB-containing neurons and those immunoreactive to excitatory amino acids. Double immunocytochemistry of ASP and CB or GLU and CB was performed in 40-microm-thick sections. The three markers were distributed in the thalamic midline, mediodorsal, anterior intralaminar and ventromedial nuclei, with regional variations. ASP-immunoreactive neurons appeared more numerous than the GLU-immunoreactive ones throughout these structures; ASP-CB or GLU-CB double-immunostained neurons were evident. ASP-, GLU- and CB-immunoreactive cells were then quantitatively evaluated in 5-microm-thick consecutive sections. Interindividual variations and different anti-ASP and anti-GLU antibodies did not result in significant differences. ASP and GLU were not co-localized. Single ASP- or GLU-immunoreactive neurons accounted for 60% of the total number of immunostained cells, and single ASP-immunopositive cells represented more than half of these neurons. Among the CB-immunoreactive cells (40% of the total), half were double immunostained; the proportion of double CB-ASP-immunopositive neurons was sevenfold higher than that of the CB-GLU-immunoreactive ones. These results indicate that ASP may act as excitatory neurotransmitter in a relatively high proportion of medial thalamic neurons, in which ASP frequently coexists with CB. Approximately 50% of the CB-immunoreactive cells did not contain either ASP or GLU, suggesting that some medial thalamic neurons may utilize a different neurotransmitter. | lld:pubmed |
| pubmed-article:9224837 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9224837 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9224837 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9224837 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9224837 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9224837 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9224837 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9224837 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9224837 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9224837 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9224837 | pubmed:issn | 0014-4819 | lld:pubmed |
| pubmed-article:9224837 | pubmed:author | pubmed-author:BentivoglioMM | lld:pubmed |
| pubmed-article:9224837 | pubmed:author | pubmed-author:SpreaficoRR | lld:pubmed |
| pubmed-article:9224837 | pubmed:author | pubmed-author:FrassoniCC | lld:pubmed |
| pubmed-article:9224837 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9224837 | pubmed:volume | 115 | lld:pubmed |
| pubmed-article:9224837 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9224837 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9224837 | pubmed:pagination | 95-104 | lld:pubmed |
| pubmed-article:9224837 | pubmed:dateRevised | 2009-11-11 | lld:pubmed |
| pubmed-article:9224837 | pubmed:meshHeading | pubmed-meshheading:9224837-... | lld:pubmed |
| pubmed-article:9224837 | pubmed:meshHeading | pubmed-meshheading:9224837-... | lld:pubmed |
| pubmed-article:9224837 | pubmed:meshHeading | pubmed-meshheading:9224837-... | lld:pubmed |
| pubmed-article:9224837 | pubmed:meshHeading | pubmed-meshheading:9224837-... | lld:pubmed |
| pubmed-article:9224837 | pubmed:meshHeading | pubmed-meshheading:9224837-... | lld:pubmed |
| pubmed-article:9224837 | pubmed:meshHeading | pubmed-meshheading:9224837-... | lld:pubmed |
| pubmed-article:9224837 | pubmed:meshHeading | pubmed-meshheading:9224837-... | lld:pubmed |
| pubmed-article:9224837 | pubmed:meshHeading | pubmed-meshheading:9224837-... | lld:pubmed |
| pubmed-article:9224837 | pubmed:meshHeading | pubmed-meshheading:9224837-... | lld:pubmed |
| pubmed-article:9224837 | pubmed:meshHeading | pubmed-meshheading:9224837-... | lld:pubmed |
| pubmed-article:9224837 | pubmed:meshHeading | pubmed-meshheading:9224837-... | lld:pubmed |
| pubmed-article:9224837 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9224837 | pubmed:articleTitle | Glutamate, aspartate and co-localization with calbindin in the medial thalamus. An immunohistochemical study in the rat. | lld:pubmed |
| pubmed-article:9224837 | pubmed:affiliation | Dipartimento di Neurofisiologia, Istituto Nazionale Neurologico C. Besta, Milano, Italy. | lld:pubmed |
| pubmed-article:9224837 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9224837 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9224837 | lld:pubmed |
