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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1997-9-8
|
| pubmed:abstractText |
Wool fatty alcohols (WF-Alc; C10-C33), separated by esterolysis of wool grease secreted from sheep sebaceous gland, inhibited growth of mouse Ehrlich ascites carcinoma (EAC) cells in contrast to no inhibition by unesterolysed wool grease. WF-Alc was fractionated by molecular distillation and subsequent octadecylsilica (ODS) gel liquid chromatography, showing that most of the growth-inhibitory activity was found in the most hydrophilic fraction with the lowest boiling-point (MW 200-300; C12-C20), ODS-HPLC of the fraction showed that most of the activity resided in two homogeneous fractions identified by GC-MS and 13C-/1H-NMR as alpha, beta-dihydric saturated fatty alcohols such as 1,2-hexadecanediol (n-C16(OH)2) and 16-methyl-1,2-heptadecanediol (iso-C18(OH)2), respectively. EAC cells implanted into mice were inhibited markedly by n-C16(OH)2 possessing a cytolysing ability and slightly by iso-C18(OH)2, but hardly by other alkyl-alpha, beta-diols (C12-C24) contained in WF-Alc. Thus, the antitumor activity of WF-Alc was exhibited only after saponification of uncytotoxic wool grease, showing necessity of unesterified hydroxyl groups, and was dependent upon the molecular hydrophobicity balance attributed to both hydroxyl groups and n- or iso-alkyl moiety bulkiness specified out of diverse species of fatty alcohols contained in WF-Alc.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0305-7232
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
221-33
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:9224558-Animals,
pubmed-meshheading:9224558-Antineoplastic Agents,
pubmed-meshheading:9224558-Carcinoma, Ehrlich Tumor,
pubmed-meshheading:9224558-Chemistry, Physical,
pubmed-meshheading:9224558-Chromatography, High Pressure Liquid,
pubmed-meshheading:9224558-Drug Screening Assays, Antitumor,
pubmed-meshheading:9224558-Fatty Alcohols,
pubmed-meshheading:9224558-Gas Chromatography-Mass Spectrometry,
pubmed-meshheading:9224558-Lung Neoplasms,
pubmed-meshheading:9224558-Magnetic Resonance Spectroscopy,
pubmed-meshheading:9224558-Mice,
pubmed-meshheading:9224558-Mice, Inbred C57BL,
pubmed-meshheading:9224558-Neuroblastoma,
pubmed-meshheading:9224558-Physicochemical Phenomena,
pubmed-meshheading:9224558-Sheep,
pubmed-meshheading:9224558-Skin,
pubmed-meshheading:9224558-Structure-Activity Relationship,
pubmed-meshheading:9224558-Tumor Cells, Cultured,
pubmed-meshheading:9224558-Waxes,
pubmed-meshheading:9224558-Wool
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Cytotoxicity to tumors by alpha, beta-dihydric long-chain fatty alcohols isolated from esterolysates of uncytotoxic sheep cutaneous wax: the dependence on the molecular hydrophobicity balance of N- or iso-alkyl moiety bulkiness and two hydroxyl groups.
|
| pubmed:affiliation |
Division of Cell Biochemistry, Hiroshima Prefectural University School of BioScience, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|