Linked Life Data

9224425

Source:http://linkedlifedata.com/resource/pubmed/id/9224425

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1997-8-12
pubmed:abstractText
The C-Myc oncoprotein was examined in anterior latissimus dorsi (ALD) muscles of young (6 weeks) and aged (90 weeks) quail after 0.5 hours to 14 days of stretch. Western analyses of nuclear extracts showed an increase in the C-Myc oncoprotein after 1 h of stretch in young adult birds, and C-Myc remained elevated for 3 days of stretch. The onset and total accumulation of the C-Myc oncoprotein was less in muscles from aged quail as compared to muscles from young adult birds. Immunocytochemical analyses showed that C-Myc was localized in nuclei and averaged 0.2 +/- 0.04 nuclei/muscles fiber cross-section (n/f) in control muscles. C-Myc immunopositive nuclei were more numerous in muscles from young adult birds (1.7 +/- 0.2 n/f) compared to aged birds (1.1 +/- 0.1 n/f) after 2-12 h of stretch. C-Myc positive nuclei declined to 0.7 +/- 0.1 n/f after 3 days of stretch, in muscles from young adult birds; however, this was greater than in muscles from aged birds at the same time point (0.3 +/- 0.04 n/f). Many nuclei that were associated with muscle fibers expressed the C-Myc oncoprotein but did not incorporate bromodeoxyuridine, a marker of DNA synthesis and activated satellite cells. These data show a decreased ability of skeletal muscles from aged quails to initiate a program inclusive of early C-Myc oncoprotein accumulation in response to stretch.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1079-5006
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
B203-11
pubmed:dateRevised
2011-9-22
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Overload-induced C-Myc oncoprotein is reduced in aged skeletal muscle.
pubmed:affiliation
Department of Anatomy, College of Medicine, H.E. Lee Moffit Cancer Center and Research Institute, Tampa, USA. salway@coml.med.usf.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.