Linked Life Data

9223595

Source:http://linkedlifedata.com/resource/pubmed/id/9223595

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-9-16
pubmed:abstractText
The expression and Triton X-100 (Triton) solubility of neuronal intermediate filament proteins were determined in the developing rat cerebral cortex. The level of expression of alpha-internexin was unchanged from embryonic day 15 (E15) to postnatal day 15 (P15), whereas expression of the mid-sized neurofilament subunit increased continually during this interval concomitant with a reduction in Triton solubility of the two proteins. The low molecular weight neurofilament subunit, first barely detected at P2, was largely insoluble in Triton from the initial time point that its solubility could be assayed, at P5, to P15. Similar expression patterns and Triton solubility profiles were obtained for neuronal intermediate filament proteins in cultured neurons from E15 cerebral cortex. These results suggest that alpha-internexin is expressed earlier than neurofilament proteins to provide a more plastic network in the early developing brain. The incorporation of neurofilament proteins apparently results in the formation of the more stable intermediate filament network found in mature neurons.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
229
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
77-80
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Developmentally regulated stabilization of neuronal intermediate filaments in rat cerebral cortex.
pubmed:affiliation
McGill University, Department of Biochemistry, Montreal, Quebec, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't