| pubmed-article:9223337 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9223337 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:9223337 | lifeskim:mentions | umls-concept:C0080093 | lld:lifeskim |
| pubmed-article:9223337 | lifeskim:mentions | umls-concept:C0107103 | lld:lifeskim |
| pubmed-article:9223337 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:9223337 | lifeskim:mentions | umls-concept:C1637379 | lld:lifeskim |
| pubmed-article:9223337 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:9223337 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:9223337 | pubmed:dateCreated | 1997-8-27 | lld:pubmed |
| pubmed-article:9223337 | pubmed:abstractText | Although neurotrophins have traditionally been regarded as neuronal survival factors, recent work has suggested a role for these factors in synaptic plasticity. In particular, brain-derived neurotrophic factor (BDNF) rapidly enhances synaptic transmission in hippocampal neurons through trkB receptor stimulation and postsynaptic phosphorylation mechanisms. Activation of trkB also modulates hippocampal long-term potentiation, in which postsynaptic N-methyl-D-aspartate glutamate receptors play a key role. However, the final common pathway through which BDNF increases postsynaptic responsiveness is unknown. We now report that BDNF, within 5 min of exposure, elicits a dose-dependent increase in phosphorylation of the N-methyl-D-aspartate receptor subunit 1. This acute effect occurred in hippocampal synaptoneurosomes, which contain pre- and postsynaptic elements, and in isolated hippocampal postsynaptic densities. Nerve growth factor, in contrast, caused no enhancement of phosphorylation. These results suggest a potential mechanism for trophin-induced potentiation of synaptic transmission. | lld:pubmed |
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| pubmed-article:9223337 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9223337 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9223337 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9223337 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9223337 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:9223337 | pubmed:author | pubmed-author:BlackI BIB | lld:pubmed |
| pubmed-article:9223337 | pubmed:author | pubmed-author:WuKK | lld:pubmed |
| pubmed-article:9223337 | pubmed:author | pubmed-author:TANY CYC | lld:pubmed |
| pubmed-article:9223337 | pubmed:author | pubmed-author:FuJ ZJZ | lld:pubmed |
| pubmed-article:9223337 | pubmed:author | pubmed-author:LevineE SES | lld:pubmed |
| pubmed-article:9223337 | pubmed:author | pubmed-author:MountH THT | lld:pubmed |
| pubmed-article:9223337 | pubmed:author | pubmed-author:SuenP CPC | lld:pubmed |
| pubmed-article:9223337 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9223337 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:9223337 | pubmed:volume | 94 | lld:pubmed |
| pubmed-article:9223337 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9223337 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9223337 | pubmed:pagination | 8191-5 | lld:pubmed |
| pubmed-article:9223337 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9223337 | pubmed:meshHeading | pubmed-meshheading:9223337-... | lld:pubmed |
| pubmed-article:9223337 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9223337 | pubmed:articleTitle | Brain-derived neurotrophic factor rapidly enhances phosphorylation of the postsynaptic N-methyl-D-aspartate receptor subunit 1. | lld:pubmed |
| pubmed-article:9223337 | pubmed:affiliation | Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA. | lld:pubmed |
| pubmed-article:9223337 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9223337 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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