|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1997-7-17
|
|
pubmed:abstractText |
Tumor necrosis factor (TNF) is a proinflammatory cytokine involved in the pathogenesis of rheumatoid arthritis, and antagonism of TNF may reduce the activity of the disease. This study evaluated the safety and efficacy of a novel TNF antagonist - a recombinant fusion protein that consists of the soluble TNF receptor (p75) linked to the Fc portion of human IgG1 (TNFR:Fc).
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0028-4793
|
|
pubmed:author |
pubmed-author:BaumgartnerS WSW,
pubmed-author:BloschC MCM,
pubmed-author:CohenSS,
pubmed-author:EttlingerR ERE,
pubmed-author:FleischmannR MRM,
pubmed-author:KoopmanW JWJ,
pubmed-author:MohlerKK,
pubmed-author:MorelandL WLW,
pubmed-author:SchiffM HMH,
pubmed-author:TindallE AEA,
pubmed-author:WeaverA LAL,
pubmed-author:WidmerM BMB
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
17
|
|
pubmed:volume |
337
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
141-7
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:9219699-Antibodies,
pubmed-meshheading:9219699-Antigens, CD,
pubmed-meshheading:9219699-Arthritis, Rheumatoid,
pubmed-meshheading:9219699-Dose-Response Relationship, Drug,
pubmed-meshheading:9219699-Double-Blind Method,
pubmed-meshheading:9219699-Female,
pubmed-meshheading:9219699-Humans,
pubmed-meshheading:9219699-Immunoglobulin Fc Fragments,
pubmed-meshheading:9219699-Immunoglobulin G,
pubmed-meshheading:9219699-Male,
pubmed-meshheading:9219699-Middle Aged,
pubmed-meshheading:9219699-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:9219699-Receptors, Tumor Necrosis Factor, Type II,
pubmed-meshheading:9219699-Recombinant Fusion Proteins,
pubmed-meshheading:9219699-Treatment Outcome
|
|
pubmed:year |
1997
|
|
pubmed:articleTitle |
Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein.
|
|
pubmed:affiliation |
University of Alabama at Birmingham, 35294-7201, USA.
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
|
