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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1997-9-4
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pubmed:abstractText |
Natural killer (NK) cells preferentially express several type II glycoproteins of the calcium-dependent lectin superfamily. The genes coding for these molecules are clustered on the distal mouse chromosome 6 and on the rat chromosome 4 in a region designated the NK gene complex. To date, no definite evidence of the presence of a NK gene complex has been found in humans. Here we report the assignment by fluorescence in situ hybridization of the CD94 gene to human chromosome 12p12-p13, in the same region where the CD69 and NKG2A genes had been previously mapped. In addition, using a yeast artificial chromosome contig spanning this region we determined that the human CD94, NKG2A, NKG2C, NKG2E, and NKR-P1A (NKR) genes map to the short arm of chromosome 12. The distal to proximal position of these loci are: NKR- CD69 - CD94/NKG2A/NKG2C/NKG2E. These data demonstrate the existence of a human NK gene complex located within a 5.6 cM interval flanked by the genetic markers D12S397 and D12S89. The physical distance spanned by the NK gene complex in humans ranges between 0.7 and 2.4 megabases.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/CD69 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/KLRC1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/KLRC2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/KLRC3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/KLRD1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Klrc1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Klrc2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Klrc3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Klrd1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Mitogen,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Natural Killer Cell
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pubmed:status |
MEDLINE
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pubmed:issn |
0093-7711
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
307-11
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9218532-Animals,
pubmed-meshheading:9218532-Antigens, CD,
pubmed-meshheading:9218532-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:9218532-Chromosome Mapping,
pubmed-meshheading:9218532-Chromosomes, Artificial, Yeast,
pubmed-meshheading:9218532-Chromosomes, Human, Pair 12,
pubmed-meshheading:9218532-Humans,
pubmed-meshheading:9218532-In Situ Hybridization, Fluorescence,
pubmed-meshheading:9218532-Killer Cells, Natural,
pubmed-meshheading:9218532-Lectins,
pubmed-meshheading:9218532-Lectins, C-Type,
pubmed-meshheading:9218532-Membrane Glycoproteins,
pubmed-meshheading:9218532-Mice,
pubmed-meshheading:9218532-NK Cell Lectin-Like Receptor Subfamily C,
pubmed-meshheading:9218532-NK Cell Lectin-Like Receptor Subfamily D,
pubmed-meshheading:9218532-Rats,
pubmed-meshheading:9218532-Receptors, Immunologic,
pubmed-meshheading:9218532-Receptors, Mitogen,
pubmed-meshheading:9218532-Receptors, Natural Killer Cell
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pubmed:year |
1997
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pubmed:articleTitle |
The human natural killer gene complex is located on chromosome 12p12-p13.
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pubmed:affiliation |
Unidad de Biología Molecular, Hospital de la Princesa, Universidad Autónoma de Madrid, c/Diego de León 62, Madrid 28006, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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