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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1997-8-11
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pubmed:abstractText |
Streptozotocin (STZ)-induced diabetes in Wistar rats results in severe hyperlipidemia and a characteristic cardiomyopathy. However, Wistar-Kyoto (WKY) rats made diabetic with a similar dose of STZ did not develop heart dysfunction or hypertriglyceridemia at 12 weeks post-STZ. We investigated whether an apparent resistance of the WKY strain to develop diabetic cardiomyopathy and hypertriglyceridemia following chronic diabetes could be due to a reduced susceptibility to the diabetogenic effects of STZ.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0008-6363
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
199-205
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9217891-Animals,
pubmed-meshheading:9217891-Cardiomyopathies,
pubmed-meshheading:9217891-Diabetes Mellitus, Experimental,
pubmed-meshheading:9217891-Disease Susceptibility,
pubmed-meshheading:9217891-Dose-Response Relationship, Drug,
pubmed-meshheading:9217891-Hypertriglyceridemia,
pubmed-meshheading:9217891-Lipoprotein Lipase,
pubmed-meshheading:9217891-Rats,
pubmed-meshheading:9217891-Rats, Inbred WKY,
pubmed-meshheading:9217891-Rats, Wistar,
pubmed-meshheading:9217891-Species Specificity,
pubmed-meshheading:9217891-Streptozocin,
pubmed-meshheading:9217891-Time Factors
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pubmed:year |
1997
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pubmed:articleTitle |
Strain differences in susceptibility to streptozotocin-induced diabetes: effects on hypertriglyceridemia and cardiomyopathy.
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pubmed:affiliation |
Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancourer, Canada.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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