| pubmed-article:9217698 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9217698 | lifeskim:mentions | umls-concept:C0018081 | lld:lifeskim |
| pubmed-article:9217698 | lifeskim:mentions | umls-concept:C0027573 | lld:lifeskim |
| pubmed-article:9217698 | lifeskim:mentions | umls-concept:C0033105 | lld:lifeskim |
| pubmed-article:9217698 | lifeskim:mentions | umls-concept:C0370215 | lld:lifeskim |
| pubmed-article:9217698 | lifeskim:mentions | umls-concept:C0039649 | lld:lifeskim |
| pubmed-article:9217698 | lifeskim:mentions | umls-concept:C0016993 | lld:lifeskim |
| pubmed-article:9217698 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9217698 | pubmed:dateCreated | 1997-8-7 | lld:pubmed |
| pubmed-article:9217698 | pubmed:abstractText | One hundred and three strains of Neisseria gonorrhoeae isolated from a periurban STD clinic in The Gambia were studied for antimicrobial susceptibility, plasmid profile, and serogroup using standard procedures. Seventy-nine (77%) were penicillinase producers (PPNG) and fully resistant to penicillin (MIC > or = 8 mg/l). One isolate showed chromosomally induced resistance to penicillin (MIC 2 mg/l). None of the isolates was sensitive to tetracycline; 16 (16%) showed intermediate resistance (MICs 1-8 mg/l) and 87 (84%) showed high-level plasmid-mediated resistance (TRNG) (MICs > 10 mg/l). This is the first report of TRNG in The Gambia. Only 6 (6%) strains were fully sensitive to trimethoprim-sulphamethoxazole (MIC < 8 mg/l); 78 (76%) showed intermediate level resistance (MICs 8-16 mg/l) and 19 (18%) were fully resistant (MIC > 32 mg/l). Indications of an increase in MIC to ciprofloxacin and ceftriaxone were found in 6 (6%) and 1 (1%) strains, respectively, although all remained fully sensitive (MICs 0.004-0.03 mg/l and 0.001-0.015 mg/l). All PPNG and TRNG strains carried the 3.2 MDa and 25.2 MDa plasmids, respectively. All isolates carried the 2.6 MDa cryptic plasmid and 9 (3 PPNG and 6 non-PPNG) carried the 24.5 MDa conjugative plasmid. Forty-four (43%) strains were typed group W1, 58 (56%) W11/111 and 1 had cross-reacting antigens. Because PPNG are frequently encountered and high-level TRNG is now prevalent, the newer cephalosporins and quinolones must now be considered as first-line drugs for the treatment of gonorrhoea in The Gambia. | lld:pubmed |
| pubmed-article:9217698 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9217698 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9217698 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9217698 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9217698 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9217698 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9217698 | pubmed:month | May | lld:pubmed |
| pubmed-article:9217698 | pubmed:issn | 1360-2276 | lld:pubmed |
| pubmed-article:9217698 | pubmed:author | pubmed-author:WestBB | lld:pubmed |
| pubmed-article:9217698 | pubmed:author | pubmed-author:CorrahTT | lld:pubmed |
| pubmed-article:9217698 | pubmed:author | pubmed-author:MabeyDD | lld:pubmed |
| pubmed-article:9217698 | pubmed:author | pubmed-author:AdegbolaR ARA | lld:pubmed |
| pubmed-article:9217698 | pubmed:author | pubmed-author:SaballySS | lld:pubmed |
| pubmed-article:9217698 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9217698 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:9217698 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9217698 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9217698 | pubmed:pagination | 428-32 | lld:pubmed |
| pubmed-article:9217698 | pubmed:dateRevised | 2006-11-7 | lld:pubmed |
| pubmed-article:9217698 | pubmed:meshHeading | pubmed-meshheading:9217698-... | lld:pubmed |
| pubmed-article:9217698 | pubmed:meshHeading | pubmed-meshheading:9217698-... | lld:pubmed |
| pubmed-article:9217698 | pubmed:meshHeading | pubmed-meshheading:9217698-... | lld:pubmed |
| pubmed-article:9217698 | pubmed:meshHeading | pubmed-meshheading:9217698-... | lld:pubmed |
| pubmed-article:9217698 | pubmed:meshHeading | pubmed-meshheading:9217698-... | lld:pubmed |
| pubmed-article:9217698 | pubmed:meshHeading | pubmed-meshheading:9217698-... | lld:pubmed |
| pubmed-article:9217698 | pubmed:meshHeading | pubmed-meshheading:9217698-... | lld:pubmed |
| pubmed-article:9217698 | pubmed:meshHeading | pubmed-meshheading:9217698-... | lld:pubmed |
| pubmed-article:9217698 | pubmed:meshHeading | pubmed-meshheading:9217698-... | lld:pubmed |
| pubmed-article:9217698 | pubmed:meshHeading | pubmed-meshheading:9217698-... | lld:pubmed |
| pubmed-article:9217698 | pubmed:meshHeading | pubmed-meshheading:9217698-... | lld:pubmed |
| pubmed-article:9217698 | pubmed:meshHeading | pubmed-meshheading:9217698-... | lld:pubmed |
| pubmed-article:9217698 | pubmed:meshHeading | pubmed-meshheading:9217698-... | lld:pubmed |
| pubmed-article:9217698 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9217698 | pubmed:articleTitle | Increasing prevalence of penicillinase-producing Neisseria gonorrhoeae and the emergence of high-level, plasmid-mediated tetracycline resistance among gonococcal isolates in The Gambia. | lld:pubmed |
| pubmed-article:9217698 | pubmed:affiliation | Medical Research Council Laboratories, Fajara, The Gambia. | lld:pubmed |
| pubmed-article:9217698 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9217698 | lld:pubmed |
