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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1997-8-7
|
| pubmed:abstractText |
One hundred and three strains of Neisseria gonorrhoeae isolated from a periurban STD clinic in The Gambia were studied for antimicrobial susceptibility, plasmid profile, and serogroup using standard procedures. Seventy-nine (77%) were penicillinase producers (PPNG) and fully resistant to penicillin (MIC > or = 8 mg/l). One isolate showed chromosomally induced resistance to penicillin (MIC 2 mg/l). None of the isolates was sensitive to tetracycline; 16 (16%) showed intermediate resistance (MICs 1-8 mg/l) and 87 (84%) showed high-level plasmid-mediated resistance (TRNG) (MICs > 10 mg/l). This is the first report of TRNG in The Gambia. Only 6 (6%) strains were fully sensitive to trimethoprim-sulphamethoxazole (MIC < 8 mg/l); 78 (76%) showed intermediate level resistance (MICs 8-16 mg/l) and 19 (18%) were fully resistant (MIC > 32 mg/l). Indications of an increase in MIC to ciprofloxacin and ceftriaxone were found in 6 (6%) and 1 (1%) strains, respectively, although all remained fully sensitive (MICs 0.004-0.03 mg/l and 0.001-0.015 mg/l). All PPNG and TRNG strains carried the 3.2 MDa and 25.2 MDa plasmids, respectively. All isolates carried the 2.6 MDa cryptic plasmid and 9 (3 PPNG and 6 non-PPNG) carried the 24.5 MDa conjugative plasmid. Forty-four (43%) strains were typed group W1, 58 (56%) W11/111 and 1 had cross-reacting antigens. Because PPNG are frequently encountered and high-level TRNG is now prevalent, the newer cephalosporins and quinolones must now be considered as first-line drugs for the treatment of gonorrhoea in The Gambia.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
1360-2276
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
428-32
|
| pubmed:dateRevised |
2006-11-7
|
| pubmed:meshHeading |
pubmed-meshheading:9217698-Anti-Bacterial Agents,
pubmed-meshheading:9217698-Drug Resistance, Microbial,
pubmed-meshheading:9217698-Gambia,
pubmed-meshheading:9217698-Gonorrhea,
pubmed-meshheading:9217698-Humans,
pubmed-meshheading:9217698-Microbial Sensitivity Tests,
pubmed-meshheading:9217698-Neisseria gonorrhoeae,
pubmed-meshheading:9217698-Penicillin Resistance,
pubmed-meshheading:9217698-Penicillinase,
pubmed-meshheading:9217698-Plasmids,
pubmed-meshheading:9217698-Prevalence,
pubmed-meshheading:9217698-Seroepidemiologic Studies,
pubmed-meshheading:9217698-Tetracycline Resistance
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Increasing prevalence of penicillinase-producing Neisseria gonorrhoeae and the emergence of high-level, plasmid-mediated tetracycline resistance among gonococcal isolates in The Gambia.
|
| pubmed:affiliation |
Medical Research Council Laboratories, Fajara, The Gambia.
|
| pubmed:publicationType |
Journal Article
|