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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1997-8-1
|
| pubmed:abstractText |
Paraneoplastic limbic encephalitis (LE) is considered a particular manifestation of paraneoplastic encephalomyelitis (PEM), a remote effect of cancer almost always associated with anti-neuronal antibodies (anti-Hu; also called ANNA 1) and small cell lung carcinoma (SCLC). In order to define the frequency of anti-Hu antibodies in LE with SCLC and to analyse possible clinical differences between patients with and without anti-Hu antibodies, the charts of 16 patients with LE and SCLC were reviewed. Eight patients (50%) had anti-Hu antibodies (anti-Hu+) whereas eight patients (50%) had no detectable anti-neuronal antibodies (anti-Hu-). The clinical and laboratory features of LE and time to diagnosis of SCLC were similar in the anti-Hu+ and anti-Hu- groups. Involvement of other areas of the nervous system compatible with the diagnosis of PEM was observed in seven (87.5%) patients of the anti-Hu+ group but in only one (12.5%) of the anti-Hu- group (P = 0.012). Five patients, including four of the anti-Hu- group, had a partial improvement of the LE after treatment of the SCLC. Another anti-Hu- patient improved spontaneously. Six patients of the anti-Hu+ group died from the neurological disorder, whereas in the anti-Hu- group the cause of death was progression of the SCLC in the three patients who died. The results of this study indicate that the absence of anti-Hu antibodies does not rule out the presence of an underlying SCLC in patients with a clinical diagnosis of LE. Patients with LE and SCLC who are without anti-Hu antibodies are less likely to develop PEM and seem to improve more often after treatment of the cancer than those who present anti-Hu antibodies.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Anti-Idiotypic,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Hu Paraneoplastic...,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA-Binding Proteins
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0006-8950
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
120 ( Pt 6)
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
923-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9217677-Antibodies, Anti-Idiotypic,
pubmed-meshheading:9217677-Autoantibodies,
pubmed-meshheading:9217677-Carcinoma, Small Cell,
pubmed-meshheading:9217677-Cerebrospinal Fluid,
pubmed-meshheading:9217677-Encephalitis,
pubmed-meshheading:9217677-Female,
pubmed-meshheading:9217677-Follow-Up Studies,
pubmed-meshheading:9217677-Hu Paraneoplastic Encephalomyelitis Antigens,
pubmed-meshheading:9217677-Humans,
pubmed-meshheading:9217677-Immunoblotting,
pubmed-meshheading:9217677-Immunosuppression,
pubmed-meshheading:9217677-Limbic System,
pubmed-meshheading:9217677-Lung Neoplasms,
pubmed-meshheading:9217677-Lymphocytes,
pubmed-meshheading:9217677-Magnetic Resonance Imaging,
pubmed-meshheading:9217677-Male,
pubmed-meshheading:9217677-Middle Aged,
pubmed-meshheading:9217677-Nerve Tissue Proteins,
pubmed-meshheading:9217677-Paraneoplastic Syndromes,
pubmed-meshheading:9217677-RNA-Binding Proteins,
pubmed-meshheading:9217677-Retrospective Studies
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Limbic encephalitis and small cell lung cancer. Clinical and immunological features.
|
| pubmed:affiliation |
Department of Neurology, Hôpital de la Salpêtrière, Paris, France.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|