Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1997-7-31
|
| pubmed:abstractText |
Malondialdehyde (MDA) is one of the most frequently used indicators of lipid peroxidation. To generate reliable reference intervals for plasma malondialdehyde (P-MDA), a reference sample group was established in Funen, Denmark. The group consisted of 213 individuals (107 men, 106 women), ages 20-79 years. P-MDA was measured in EDTA-treated plasma after derivatization by thiobarbituric acid (TBA) and separation on HPLC. UV detection was performed at 532 nm. A reference interval was calculated as recommended by IFCC with REFVAL 3.42. The estimated reference limits (0.025 and 0.975 fractals) for the group were 0.36 and 1.24 mumol/L. The data were analyzed for gender- and age-related differences. Analysis of variance showed no interaction between gender and age, but separate analyses showed an independent effect of gender (P = 0.03), but not of age (P = 0.11). Daily smokers had a slightly higher average concentration of P-MDA than nonsmokers (P = 0.05), and P-MDA correlated with daily exposure to cigarette smoke (r = 0.162; P = 0.03). A positive correlation was also demonstrated between P-MDA and weekly alcohol consumption (r = 0.153; P = 0.03). Within-subject and day-to-day variations of P-MDA indicated that the potential of P-MDA as a biomarker for individuals is questionable. However, on a group basis, the present data support that P-MDA may be a potential biomarker for oxidative stress.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0009-9147
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
43
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1209-14
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9216458-Adult,
pubmed-meshheading:9216458-Aged,
pubmed-meshheading:9216458-Aging,
pubmed-meshheading:9216458-Alcohol Drinking,
pubmed-meshheading:9216458-Biological Markers,
pubmed-meshheading:9216458-Chromatography, High Pressure Liquid,
pubmed-meshheading:9216458-Denmark,
pubmed-meshheading:9216458-Female,
pubmed-meshheading:9216458-Humans,
pubmed-meshheading:9216458-Life Style,
pubmed-meshheading:9216458-Male,
pubmed-meshheading:9216458-Malondialdehyde,
pubmed-meshheading:9216458-Middle Aged,
pubmed-meshheading:9216458-Oxidative Stress,
pubmed-meshheading:9216458-Reference Values,
pubmed-meshheading:9216458-Reproducibility of Results,
pubmed-meshheading:9216458-Sensitivity and Specificity,
pubmed-meshheading:9216458-Sex Characteristics,
pubmed-meshheading:9216458-Smoking,
pubmed-meshheading:9216458-Thiobarbiturates
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Plasma malondialdehyde as biomarker for oxidative stress: reference interval and effects of life-style factors.
|
| pubmed:affiliation |
Institute of Community Health, Odense University, Denmark. F.Nielsen@Winsloew.ou.dk
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|