Linked Life Data

9216212

Source:http://linkedlifedata.com/resource/pubmed/id/9216212

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1997-9-23
pubmed:abstractText
Pulmonary surfactant is synthesized and secreted by alveolar type II cells. The major components of surfactant are phospholipids and four distinct surfactant-specific proteins: SP-A, SP-B, SP-C, and SP-D. The concentrations of SP-D and SP-A were measured in sera of patients with idiopathic interstitial pneumonia (IIP), by enzyme-linked immunosorbent assay with monoclonal antibodies against human SP-D and SP-A. The concentrations of SP-D and SP-A in samples from the patients were, respectively, 5.7 and 2.8 times higher than those in samples from healthy volunteers; 86.2% and 71.4% of the patients had concentrations of SP-D and SP-A, respectively, that were more than 2 standard deviations greater than the mean of the control values. Moreover, the serum SP-D and SP-A concentrations appeared to reflect the disease activity of IIP. There was a negative significant correlation between the concentrations of SP-A in serum and in bronchoalveolar lavage fluid. These results suggest that SP-D and SP-A, which are primarily secreted from alveolar type II cells into the alveolar lumen, can enter the bloodstream easily due to injury at the alveolar-capillary membrane. We conclude that measurement of SP-D and SP-A in sera can provide an easily identifiable and useful clinical marker for the diagnosis of IIP, and can be used to predict the disease activity of IIP.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0301-1542
pubmed:author
pubmed:issnType
Print
pubmed:volume
34 Suppl
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
181-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
[Clinical significance of serum surfactant proteins A and D in idiopathic interstitial pneumonia].
pubmed:affiliation
Third Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan.
pubmed:publicationType
Journal Article, English Abstract