|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1997-8-26
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|
pubmed:abstractText |
The effect of 4-hydroxynonenal (4-HNE), a circulating lipid peroxidation product, on the vascular tone of human mesenteric arteries is studied. 4-HNE promotes relaxation of human mesenteric arterial rings in a concentration-dependent manner. Removal of the endothelium or treatment with N(G)-nitro-L-arginine methyl ester hydrochloride (L-NAME; 10(-4) M) partially prevented 4-HNE-induced relaxation, thus suggesting the intervention of nitric oxide from endothelial origin in the vascular effects of 4-HNE.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0891-5849
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
23
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
521-3
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:9214591-Adult,
pubmed-meshheading:9214591-Aged,
pubmed-meshheading:9214591-Aldehydes,
pubmed-meshheading:9214591-Endothelium, Vascular,
pubmed-meshheading:9214591-Female,
pubmed-meshheading:9214591-Hemodynamics,
pubmed-meshheading:9214591-Humans,
pubmed-meshheading:9214591-Lipid Peroxidation,
pubmed-meshheading:9214591-Male,
pubmed-meshheading:9214591-Mesenteric Arteries,
pubmed-meshheading:9214591-Middle Aged,
pubmed-meshheading:9214591-Muscle, Smooth, Vascular,
pubmed-meshheading:9214591-Muscle Contraction,
pubmed-meshheading:9214591-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:9214591-Nitric Oxide,
pubmed-meshheading:9214591-Norepinephrine,
pubmed-meshheading:9214591-Vasodilation
|
|
pubmed:year |
1997
|
|
pubmed:articleTitle |
4-hydroxynonenal-induced relaxation of human mesenteric arteries.
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|
pubmed:affiliation |
Department of Physiology, School of Medicine & Dentistry, University of Valencia, Spain.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
