Linked Life Data

921415

Source:http://linkedlifedata.com/resource/pubmed/id/921415

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1977-12-29
pubmed:abstractText
A central nervous origin of the hypotensive effect of a number of clonidine-like drugs was demonstrated by means of infusions of low doses into the vertebral artery of chloralose-anaesthetized cats. Systemic injections of the same amounts were significantly less effective than after their application via the central route. In addition, pretreatment with the alpha-adrenoceptor blocking agent piperoxan effectively blocked the centrally induced hypotensive response. It is concluded that imidazolidines of the clonidine-type probably display the same mechanism of action as that manifested by clonidine itself. The centrally mediated depressor response was quantified by means of an ED25. The antihypertensive and bradycardic activities of clonidine and a number of its derivatives were quantified by means of ED20 values calculated from dose-response curves following intravenous administration to conscious, spontaneously hypertensive rats. Linear relationships were found between the hypotensive activity in the anaesthetized, normotensive rat, the central hypotensive potency in the anaesthetized cat and the antihypertensive efficacy in the conscious, spontaneously hypertensive rat. These findings indicate a similarity between central alpha-adrenoceptors in these different animal species.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0301-4533
pubmed:author
pubmed:issnType
Print
pubmed:volume
228
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
251-67
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Central hypotensive and antihypertensive activities of imidazolidines, structurally related to clonidine.
pubmed:publicationType
Journal Article