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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1997-8-28
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pubmed:abstractText |
Because previous studies had suggested that the anorectic effects of cholecystokinin (CCK) and bombesin (BBS) depend partly on the release of amylin or calcitonin gene-related peptide (CGRP), we investigated the influence of the amylin and CGRP receptor antagonist CGRP (8-37) on the anorectic effects of CCK and BBS in streptozotocin (STZ)-diabetic and nondiabetic rats. STZ-diabetic rats had significantly lower plasma amylin and insulin concentrations than nondiabetic control rats. Amylin (5 micrograms/kg or 2.5 micrograms/rat) injected IP at dark onset after 24-h food deprivation elicited an anorectic effect of similar extent in STZ-diabetic and control rats. Under similar conditions, CCK (0.25 and 2 micrograms/kg) and BBS (5 micrograms/kg) reduced food intake in both STZ-diabetic and nondiabetic rats. These effects were markedly attenuated by CGRP (8-37) (10 micrograms/kg) in non-diabetics but not in STZ-diabetic rats. It is concluded that part of the anorectic effects of CCK and BBS depend on the release of amylin from pancreatic B-cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0196-9781
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
643-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:9213356-Amyloid,
pubmed-meshheading:9213356-Animals,
pubmed-meshheading:9213356-Anorexia,
pubmed-meshheading:9213356-Bombesin,
pubmed-meshheading:9213356-Calcitonin Gene-Related Peptide,
pubmed-meshheading:9213356-Cholecystokinin,
pubmed-meshheading:9213356-Diabetes Mellitus, Experimental,
pubmed-meshheading:9213356-Drug Combinations,
pubmed-meshheading:9213356-Eating,
pubmed-meshheading:9213356-Injections, Intraperitoneal,
pubmed-meshheading:9213356-Islet Amyloid Polypeptide,
pubmed-meshheading:9213356-Male,
pubmed-meshheading:9213356-Peptide Fragments,
pubmed-meshheading:9213356-Rats,
pubmed-meshheading:9213356-Streptozocin
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pubmed:year |
1997
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pubmed:articleTitle |
Different influence of CGRP (8-37), an amylin and CGRP antagonist, on the anorectic effects of cholecystokinin and bombesin in diabetic and normal rats.
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pubmed:affiliation |
Institute of Veterinary Physiology, University of Zuerich, Switzerland.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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