| pubmed-article:9213020 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9213020 | lifeskim:mentions | umls-concept:C0079925 | lld:lifeskim |
| pubmed-article:9213020 | lifeskim:mentions | umls-concept:C0011209 | lld:lifeskim |
| pubmed-article:9213020 | lifeskim:mentions | umls-concept:C0205276 | lld:lifeskim |
| pubmed-article:9213020 | lifeskim:mentions | umls-concept:C0002996 | lld:lifeskim |
| pubmed-article:9213020 | lifeskim:mentions | umls-concept:C1831626 | lld:lifeskim |
| pubmed-article:9213020 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9213020 | pubmed:dateCreated | 1997-8-21 | lld:pubmed |
| pubmed-article:9213020 | pubmed:abstractText | Intraluminal delivery of antisense oligonucleotides to c-myb was assessed following balloon angioplasty in swine peripheral arteries. Successful delivery and intramural persistence of oligonucleotide for over 24 h were demonstrated following angioplasty with hydrogel balloons coated with 32P-labeled antisense. Delivery of fluorescein-labeled antisense demonstrated further localization within the arterial media and intracellularly. Preliminary in vitro studies demonstrated the feasibility of inhibition of porcine lymphocyte proliferation using the murine antisense to c-myb. Twelve iliac or carotid arteries underwent angioplasty with antisense-coated balloons, while the contralateral vessels underwent angioplasty with the same-sized balloons coated with the complementary sense strand. Six to seven days later, dilated arterial segments were surgically isolated. In 10 of 12 vessel pairs, antisense-treated vessels demonstrated less cellular proliferation than did contralateral sense-treated vessels, as assessed by quantitative immunohistochemical staining of proliferating cell nuclear antigen, and smooth muscle cell proliferation was reduced 18% in antisense-treated vessels compared to the contralateral sense-treated vessels (PCNA-positive nuclear area: 7.7 +/- 4.9% vs. 9.3 +/- 5.2%, P < 0.04)-intraluminal delivery of antisense oligonucleotides to c-myb is feasible with a catheter-based system and may reduce smooth muscle cell proliferation following arterial injury. | lld:pubmed |
| pubmed-article:9213020 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9213020 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9213020 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9213020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9213020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9213020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9213020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9213020 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9213020 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9213020 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9213020 | pubmed:issn | 0098-6569 | lld:pubmed |
| pubmed-article:9213020 | pubmed:author | pubmed-author:WatersD DDD | lld:pubmed |
| pubmed-article:9213020 | pubmed:author | pubmed-author:PedersenC ACA | lld:pubmed |
| pubmed-article:9213020 | pubmed:author | pubmed-author:FoxP LPL | lld:pubmed |
| pubmed-article:9213020 | pubmed:author | pubmed-author:CartunR WRW | lld:pubmed |
| pubmed-article:9213020 | pubmed:author | pubmed-author:McKayR GRG | lld:pubmed |
| pubmed-article:9213020 | pubmed:author | pubmed-author:AzrinM AMA | lld:pubmed |
| pubmed-article:9213020 | pubmed:author | pubmed-author:AretzT HTH | lld:pubmed |
| pubmed-article:9213020 | pubmed:author | pubmed-author:MitchelJ FJF | lld:pubmed |
| pubmed-article:9213020 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9213020 | pubmed:volume | 41 | lld:pubmed |
| pubmed-article:9213020 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9213020 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9213020 | pubmed:pagination | 232-40 | lld:pubmed |
| pubmed-article:9213020 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:9213020 | pubmed:meshHeading | pubmed-meshheading:9213020-... | lld:pubmed |
| pubmed-article:9213020 | pubmed:meshHeading | pubmed-meshheading:9213020-... | lld:pubmed |
| pubmed-article:9213020 | pubmed:meshHeading | pubmed-meshheading:9213020-... | lld:pubmed |
| pubmed-article:9213020 | pubmed:meshHeading | pubmed-meshheading:9213020-... | lld:pubmed |
| pubmed-article:9213020 | pubmed:meshHeading | pubmed-meshheading:9213020-... | lld:pubmed |
| pubmed-article:9213020 | pubmed:meshHeading | pubmed-meshheading:9213020-... | lld:pubmed |
| pubmed-article:9213020 | pubmed:meshHeading | pubmed-meshheading:9213020-... | lld:pubmed |
| pubmed-article:9213020 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9213020 | pubmed:articleTitle | Local delivery of c-myb antisense oligonucleotides during balloon angioplasty. | lld:pubmed |
| pubmed-article:9213020 | pubmed:affiliation | Department of Internal Medicine and Cardiology, Hartford Hospital, Connecticut, USA. | lld:pubmed |
| pubmed-article:9213020 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9213020 | lld:pubmed |
