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rdf:type |
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lifeskim:mentions |
umls-concept:C0023821,
umls-concept:C0035804,
umls-concept:C0074129,
umls-concept:C0086418,
umls-concept:C0336815,
umls-concept:C0597357,
umls-concept:C0814999,
umls-concept:C1334043,
umls-concept:C1413218,
umls-concept:C1516044,
umls-concept:C1880022
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pubmed:issue |
28
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pubmed:dateCreated |
1997-8-14
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pubmed:abstractText |
Recently, a murine scavenger receptor type B class I (SR-BI) was identified that binds high density lipoprotein (HDL) and mediates the selective uptake of cholesterol esters. The human CD36 and LIMPII analogous-1 (CLA-1) receptor shows high sequence homology with SR-BI, but their functional relationship has not been determined. Transfected cells expressing CLA-1 bound HDL with a Kd of about 35 microg/ml, similar to the Kd for HDL binding to rodent SR-BI. This binding resulted in an intracellular accumulation of HDL-derived [3H]cholesterol esters without internalization or degradation of 125I-apolipoprotein. CLA-1 was strongly expressed in the adrenal gland and was also abundant in liver and testis, suggesting that CLA-1, like SR-BI, could play a role in the metabolism of HDL. However, CLA-1 was also expressed in monocytes and, like SR-BI, recognized modified forms of low density lipoproteins as well as native LDL and anionic phospholipids. These findings suggest that CLA-1 might have additional physiological functions. We found that CLA-1 recognizes apoptotic thymocytes. Our results demonstrate that CLA-1, a close structural homologue of SR-BI, is also functionally related to SR-BI and may play an important role as a "docking receptor" for HDL in connection with selective uptake of cholesterol esters. An additional role in recognition of damaged cells is suggested by these studies.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD36,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol Esters,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Lipoprotein,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Scavenger,
http://linkedlifedata.com/resource/pubmed/chemical/SCARB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Scarb1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Scavenger Receptors, Class B,
http://linkedlifedata.com/resource/pubmed/chemical/high density lipoprotein binding...,
http://linkedlifedata.com/resource/pubmed/chemical/high density lipoprotein receptors
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
272
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
17551-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9211901-Animals,
pubmed-meshheading:9211901-Antigens, CD36,
pubmed-meshheading:9211901-Apoptosis,
pubmed-meshheading:9211901-Blotting, Western,
pubmed-meshheading:9211901-Carrier Proteins,
pubmed-meshheading:9211901-Cell Line,
pubmed-meshheading:9211901-Cholesterol Esters,
pubmed-meshheading:9211901-Humans,
pubmed-meshheading:9211901-Ligands,
pubmed-meshheading:9211901-Lipoproteins, HDL,
pubmed-meshheading:9211901-Membrane Proteins,
pubmed-meshheading:9211901-Mice,
pubmed-meshheading:9211901-RNA-Binding Proteins,
pubmed-meshheading:9211901-Receptors, Immunologic,
pubmed-meshheading:9211901-Receptors, Lipoprotein,
pubmed-meshheading:9211901-Receptors, Scavenger,
pubmed-meshheading:9211901-Scavenger Receptors, Class B,
pubmed-meshheading:9211901-Thymus Gland
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pubmed:year |
1997
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pubmed:articleTitle |
Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes.
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pubmed:affiliation |
Department of Medicine, University of California, San Diego, La Jolla, California 92093-0682, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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