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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5323
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pubmed:dateCreated |
1997-7-30
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pubmed:abstractText |
BOB.1/OBF.1 is a transcriptional coactivator that is constitutively expressed in B cells and interacts with the Oct1 and Oct2 transcription factors. Upon activation of Jurkat T cells and primary murine thymocytes with phorbol esters and ionomycin, BOB.1/OBF.1 expression and transactivation function were induced. BOB.1/OBF.1 was phosphorylated at Ser184 both in vivo and in vitro, and this modification was required for inducible activation. Mutation of Ser184 also diminished transactivation function in B cells, suggesting that the activating phosphorylation that is inducible in T cells is constitutively present in B cells. Thus, BOB.1/OBF.1 is a transcriptional coactivator that is critically regulated by posttranslational modifications to mediate cell type-specific gene expression.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/HCFC1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hcfc1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Host Cell Factor C1,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Ionomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Octamer Transcription Factor-1,
http://linkedlifedata.com/resource/pubmed/chemical/POU2AF1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/POU2F1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoserine,
http://linkedlifedata.com/resource/pubmed/chemical/Pou2af1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Pou2f1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
277
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
221-5
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9211847-Amino Acid Sequence,
pubmed-meshheading:9211847-Animals,
pubmed-meshheading:9211847-B-Lymphocytes,
pubmed-meshheading:9211847-Cells, Cultured,
pubmed-meshheading:9211847-DNA-Binding Proteins,
pubmed-meshheading:9211847-Gene Expression Regulation,
pubmed-meshheading:9211847-HeLa Cells,
pubmed-meshheading:9211847-Homeodomain Proteins,
pubmed-meshheading:9211847-Host Cell Factor C1,
pubmed-meshheading:9211847-Humans,
pubmed-meshheading:9211847-Immunosuppressive Agents,
pubmed-meshheading:9211847-Ionomycin,
pubmed-meshheading:9211847-Jurkat Cells,
pubmed-meshheading:9211847-Lymphocyte Activation,
pubmed-meshheading:9211847-Mice,
pubmed-meshheading:9211847-Molecular Sequence Data,
pubmed-meshheading:9211847-Octamer Transcription Factor-1,
pubmed-meshheading:9211847-Phosphorylation,
pubmed-meshheading:9211847-Phosphoserine,
pubmed-meshheading:9211847-Recombinant Fusion Proteins,
pubmed-meshheading:9211847-T-Lymphocytes,
pubmed-meshheading:9211847-Tetradecanoylphorbol Acetate,
pubmed-meshheading:9211847-Trans-Activators,
pubmed-meshheading:9211847-Transcription Factors,
pubmed-meshheading:9211847-Transcriptional Activation
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pubmed:year |
1997
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pubmed:articleTitle |
Inducible expression and phosphorylation of coactivator BOB.1/OBF.1 in T cells.
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pubmed:affiliation |
MSZ, Institut für Medizinische Strahlenkunde und Zellforschung, Universität Würzburg, Versbacher Strasse 5, 97078 Würzburg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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