Linked Life Data

9211352

Source:http://linkedlifedata.com/resource/pubmed/id/9211352

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-9-30
pubmed:abstractText
Accumulation of extracellular matrix is important in the progression of glomerulonephritis. Since adherent cell types utilize integrins to bind and organize extracellular matrix proteins, we have assessed expression of the beta 1 integrins in sequential sections from 85 human renal biopsies and 4 normal kidneys by immunohistochemical staining. Our results demonstrate strong correlations between expression of the alpha 5 chain within the interstitium, the alpha V chain on proximal and distal tubular epithelium and the presence of chronic histological damage. Moreover, staining for interstitial alpha 5 and proximal and distal tubular alpha V were also strongly associated with expression of certain adhesion molecules (ICAM-1, VCAM-1, E-selectin and L-selectin) and the presence of macrophages within the interstitium, which have been linked, in an earlier study, with the degree of chronic histological damage and disease progression. However, in contrast to our earlier study of adhesion molecules, there were also associations between expression of integrin chains within the glomerulus and tubulointerstitium. For example, there were strong positive associations between staining for alpha 5 on glomerular endothelium and its expression on extraglomerular vascular endothelium and between both mesangial alpha 1 and podocyte alpha 3 and tubular staining for the common beta 1 subunit. While the functional significance of these associations is obscure, they suggest some kind of communication between cells in different sites in the kidney. There were also positive associations between staining for different integrins within the glomerulus, notably mesangial cell staining for alpha 2, glomerular endothelial cells staining for alpha 5 and glomerular epithelial cell alpha 3. These results suggest that there is a coordinated upregulation of integrin expression both within the tubulointerstitium and the glomerulus and that at least some of these integrins (interstitial alpha 5 and distal tubular alpha V) are associated with the expression of other adhesion molecules, macrophage infiltration and the presence of markers of disease progression (interstitial fibrosis and tubular atrophy).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0085-2538
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
103-10
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9211352-Antigens, CD, pubmed-meshheading:9211352-Antigens, CD29, pubmed-meshheading:9211352-Biopsy, pubmed-meshheading:9211352-Cell Adhesion Molecules, pubmed-meshheading:9211352-Glomerulonephritis, pubmed-meshheading:9211352-Humans, pubmed-meshheading:9211352-Integrin alpha1, pubmed-meshheading:9211352-Integrin alpha2, pubmed-meshheading:9211352-Integrin alpha3, pubmed-meshheading:9211352-Integrin alpha4, pubmed-meshheading:9211352-Integrin alpha5, pubmed-meshheading:9211352-Integrin alpha6, pubmed-meshheading:9211352-Integrin alphaV, pubmed-meshheading:9211352-Integrins, pubmed-meshheading:9211352-Kidney, pubmed-meshheading:9211352-Kidney Diseases, pubmed-meshheading:9211352-Kidney Glomerulus, pubmed-meshheading:9211352-Kidney Tubules, pubmed-meshheading:9211352-Macrophages
pubmed:year
1997
pubmed:articleTitle
Importance of the tubulointerstitium in human glomerulonephritis. II. Distribution of integrin chains beta 1, alpha 1 to 6 and alpha V.
pubmed:affiliation
Department of Medicine and Therapeutics, University of Aberdeen, Scotland, United Kingdom.
pubmed:publicationType
Journal Article, Comparative Study