|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007589,
umls-concept:C0010592,
umls-concept:C0067475,
umls-concept:C0205161,
umls-concept:C0205263,
umls-concept:C0560175,
umls-concept:C0596383,
umls-concept:C0814999,
umls-concept:C1145667,
umls-concept:C1167622,
umls-concept:C1511938,
umls-concept:C1706209,
umls-concept:C1880497,
umls-concept:C1996904,
umls-concept:C2349209,
umls-concept:C2825311
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
1997-8-6
|
|
pubmed:abstractText |
The side effects of cyclosporine (CsA)-including nephrotoxicity and abnormal differentiation of thymocytes developing in the thymus-can be decreased or even avoided using targeted conjugates of CsA, where both targeting moiety and drug are bound to water-soluble polymeric carrier based on N-(2-hydroxypropyl) methacrylamide (HPMA).
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0041-1337
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
27
|
|
pubmed:volume |
63
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1818-27
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:9210511-Acrylamides,
pubmed-meshheading:9210511-Animals,
pubmed-meshheading:9210511-Bone Marrow Transplantation,
pubmed-meshheading:9210511-CD4-Positive T-Lymphocytes,
pubmed-meshheading:9210511-CD8-Positive T-Lymphocytes,
pubmed-meshheading:9210511-Cell Differentiation,
pubmed-meshheading:9210511-Concanavalin A,
pubmed-meshheading:9210511-Cyclosporine,
pubmed-meshheading:9210511-Drug Delivery Systems,
pubmed-meshheading:9210511-Erythrocytes,
pubmed-meshheading:9210511-Female,
pubmed-meshheading:9210511-Immunosuppressive Agents,
pubmed-meshheading:9210511-Lipoproteins,
pubmed-meshheading:9210511-Male,
pubmed-meshheading:9210511-Mice,
pubmed-meshheading:9210511-Mice, Inbred BALB C,
pubmed-meshheading:9210511-Polymers,
pubmed-meshheading:9210511-Rats,
pubmed-meshheading:9210511-Thymus Gland
|
|
pubmed:year |
1997
|
|
pubmed:articleTitle |
Abnormal differentiation of thymocytes induced by free cyclosporine is avoided when cyclosporine bound to N-(2-hydroxypropyl)methacrylamide copolymer carrier is used.
|
|
pubmed:affiliation |
Institute of Microbiology, Academy of Sciences of the Czech Republic, Department of Immunology and Gnotobiology, Prague.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
