Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-8-19
pubmed:abstractText
During the last 8 years 58 acute cases of Chagas' disease were studied. Patients from an endemic area of the state of Barinas, Venezuela, showed fever (98%) and circulating forms of T. cruzi (100%), and were treated with oral benznidazole. The recorded mortality was 8.6%. Acute myocarditis was constantly found either in myocardial biopsies or at necropsy, even in patients without any other sign of cardiac compromise (36%), which was detected by chest X-ray in 58%, by 2D echocardiography in 52%, by resting ECG in 41% and by clinical findings in 27.5% of the patients. Cardiomegaly was due to pericardial effusion rather than ventricular dilatation in most instances. Treatment eliminated parasitemia but negativized serology in only 20% of patients. It also appeared to have little influence on the ongoing myocarditic process, emphasizing the need for better therapeutic schedules, able to avoid or control the early appearance of immunologic mechanisms and microcirculatory damage involved in the future development of chronic chagasic myocarditis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0167-5273
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
49-54
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9209939-Acute Disease, pubmed-meshheading:9209939-Adolescent, pubmed-meshheading:9209939-Adult, pubmed-meshheading:9209939-Animals, pubmed-meshheading:9209939-Cardiomegaly, pubmed-meshheading:9209939-Chagas Cardiomyopathy, pubmed-meshheading:9209939-Child, pubmed-meshheading:9209939-Child, Preschool, pubmed-meshheading:9209939-Electrocardiography, pubmed-meshheading:9209939-Female, pubmed-meshheading:9209939-Humans, pubmed-meshheading:9209939-Infant, pubmed-meshheading:9209939-Male, pubmed-meshheading:9209939-Middle Aged, pubmed-meshheading:9209939-Myocardium, pubmed-meshheading:9209939-Nitroimidazoles, pubmed-meshheading:9209939-Pericardial Effusion, pubmed-meshheading:9209939-Trypanocidal Agents, pubmed-meshheading:9209939-Trypanosoma cruzi, pubmed-meshheading:9209939-Venezuela
pubmed:year
1997
pubmed:articleTitle
Cardiac involvement is a constant finding in acute Chagas' disease: a clinical, parasitological and histopathological study.
pubmed:affiliation
Hospital Luis Razetti, Barinas, Venezuela.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't