Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1997-8-19
|
| pubmed:abstractText |
Specific electroencephalogram (EEG) changes during clozapine therapy were prospectively studied in a cohort of 50 chronic state hospital patients with schizophrenia who were randomly assigned to one of three nonoverlapping clozapine serum level ranges (50-150 ng/mL, 200-300 ng/mL, and 350-450 ng/mL). EEGs were obtained before clozapine was instituted, and after 10 weeks of treatment. Fifty-three percent of patients showed EEG changes during the 10-week study period. We observed three seizures (6%), one in a patient on 900 mg (serum level 320 ng/mL) clozapine, and two in patients with lower clozapine serum levels (200-300 ng/mL) who had prior histories of seizures and inadequate valproate coverage. Thirteen percent of patients developed spikes with no relationship to dose or serum level of clozapine. Fifty-three percent of patients developed slowing on EEG. Compared to plasma levels below 300 ng/mL, a clozapine serum level between 350 and 450 ng/mL led to more frequent and more severe slowing. The EEG slowing correlated with observed sleepiness, although this factor was not sufficient to explain the severity of high-dose effects.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0006-3223
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
42
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
132-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9209730-Adult,
pubmed-meshheading:9209730-Antipsychotic Agents,
pubmed-meshheading:9209730-Chronic Disease,
pubmed-meshheading:9209730-Clozapine,
pubmed-meshheading:9209730-Cohort Studies,
pubmed-meshheading:9209730-Dose-Response Relationship, Drug,
pubmed-meshheading:9209730-Drug Administration Schedule,
pubmed-meshheading:9209730-Electroencephalography,
pubmed-meshheading:9209730-Evoked Potentials,
pubmed-meshheading:9209730-Female,
pubmed-meshheading:9209730-Humans,
pubmed-meshheading:9209730-Male,
pubmed-meshheading:9209730-Middle Aged,
pubmed-meshheading:9209730-Prospective Studies,
pubmed-meshheading:9209730-Psychiatric Status Rating Scales,
pubmed-meshheading:9209730-Psychotic Disorders,
pubmed-meshheading:9209730-Schizophrenia,
pubmed-meshheading:9209730-Schizophrenic Psychology,
pubmed-meshheading:9209730-Seizures
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Clozapine-induced electroencephalogram changes as a function of clozapine serum levels.
|
| pubmed:affiliation |
John Umstead Hospital, Butner, North Carolina 27509, USA.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
|