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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1997-8-7
|
| pubmed:abstractText |
Italian authors report that hepatitis C virus (HCV) infection may be one of the causes of lymphoid malignancy such as non-Hodgkin's lymphoma (NHL) and Waldenström's macroglobulinemia (WM). To assess the relationship between HCV infection and B cell malignancy (BCM) in Japan, we analyzed HCV-RNA in 50 patients with BCM [25 cases of NHL, 4 of WM and 21 of multiple myeloma (MM)] and determined genotype of infected HCV(Okamoto's classification) using reverse transcription-polymerase chain reaction assay. Eight (16.0%) of 50 patients with BCM were HCV-RNA positive [HCV(+)], while no patients were HCV(+) in control group (18 patients of non-B cell NHL). Numbers of HCV(+) cases in each group examined were as follows; four (16.0%) in B cell NHL (genotype II/III/IV were 3/1/0, respectively), one (25.0%) in WM (genotype III) and three (14.3%) in MM (genotype II/III/IV were 1/1/1, respectively). All patients examined had no symptoms and signs suggesting vasculitis. The incidence of HCV infection in the patients with BCM was markedly higher than that (approximately 1%) of healthy blood donors in Japan. We also experienced four B cell NHL cases with splenic or hepatic origin in the course of chronic hepatitis C. These results implicate the association between persistent HCV infection and the occurrence of BCM.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0887-6924
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
11 Suppl 3
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
516-8
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| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9209442-Genotype,
pubmed-meshheading:9209442-Hepacivirus,
pubmed-meshheading:9209442-Hepatitis C,
pubmed-meshheading:9209442-Humans,
pubmed-meshheading:9209442-Immunoenzyme Techniques,
pubmed-meshheading:9209442-Incidence,
pubmed-meshheading:9209442-Japan,
pubmed-meshheading:9209442-Lymphoma, B-Cell,
pubmed-meshheading:9209442-Polymerase Chain Reaction,
pubmed-meshheading:9209442-RNA, Viral,
pubmed-meshheading:9209442-Waldenstrom Macroglobulinemia
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
B cell malignancy and hepatitis C virus infection.
|
| pubmed:affiliation |
Department of Medicine, Jichi Medical School, Japan.
|
| pubmed:publicationType |
Journal Article
|