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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1997-8-7
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pubmed:abstractText |
We studied the compatibility of human lymphocyte engraftment and susceptibility to HIV-1 infection in 2 new immunodeficient mice. NOD/Shi-scid mice were generated by backcrossing of the scid mutation into NOD mice while C57BL/6-RAG2(0/0) were generated by knocking out the RAG-2 gene. Human T lymphocytes were reconstituted in new immunodeficient mouse strains. We found that the new immunodeficient mouse strains accepted human PBL engraftment and HIV-1 infection more efficiently than conventional C.B-17-scid mice. Especially in the hu-PBL-NOD/Shi-scid strain, we reproduced the high levels of HIV-1 viremia comparable to or at significantly higher levels than after HIV-1 primary infection. These results indicate that our hu-PBL-NOD-scid animal is useful for investigations of the activation mechanism in HIV-1 replication in vivo and after primary infection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0887-6924
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11 Suppl 3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
109-12
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:9209314-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:9209314-Animals,
pubmed-meshheading:9209314-CD4-Positive T-Lymphocytes,
pubmed-meshheading:9209314-CD8-Positive T-Lymphocytes,
pubmed-meshheading:9209314-Crosses, Genetic,
pubmed-meshheading:9209314-DNA, Viral,
pubmed-meshheading:9209314-DNA-Binding Proteins,
pubmed-meshheading:9209314-Disease Susceptibility,
pubmed-meshheading:9209314-HIV-1,
pubmed-meshheading:9209314-Humans,
pubmed-meshheading:9209314-Lymphocyte Transfusion,
pubmed-meshheading:9209314-Mice,
pubmed-meshheading:9209314-Mice, Inbred C57BL,
pubmed-meshheading:9209314-Mice, Inbred NOD,
pubmed-meshheading:9209314-Mice, Knockout,
pubmed-meshheading:9209314-Mice, SCID,
pubmed-meshheading:9209314-Nuclear Proteins,
pubmed-meshheading:9209314-Species Specificity,
pubmed-meshheading:9209314-Transplantation, Heterologous,
pubmed-meshheading:9209314-Viremia
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pubmed:year |
1997
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pubmed:articleTitle |
High levels of viremia in hu-PBL-NOD-scid mice with HIV-1 infection.
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pubmed:affiliation |
Department of Molecular Virology, Tokyo Medical and Dental University, Japan.
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pubmed:publicationType |
Journal Article
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