Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-7-28
pubmed:databankReference
pubmed:abstractText
Many studies have shown that voltage-gated potassium (Kv) channel activity is essential for T-lymphocyte proliferation. The IL-2-inducible neuroimmune gene, I2rf5 is the mouse homologue of the rat Kv beta 2 subunit. In this study we show that in addition to constitutive expression in adult murine brain, expression of Kv channel subunits beta 1.1 and beta 2.1 is inducible in a cloned T-helper cell line stimulated with IL-2 and in normal murine splenocytes stimulated with Con A or LPS. This expression pattern appears to be lymphocyte specific, because stimulated fibroblasts and vascular smooth muscle cells do not express Kv beta channel subunit mRNA. These observations suggest that Kv beta subunit expression is tissue specific and inducible in stimulated lymphocytes. Because Kv beta subunits modulate K+ channel activity, the inducible and variable expression of these subunits in lymphocytes may represent an additional regulatory mechanism for lymphocyte proliferation.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0165-5728
pubmed:author
pubmed:issnType
Print
pubmed:volume
77
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8-16
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:9209263-3T3 Cells, pubmed-meshheading:9209263-Animals, pubmed-meshheading:9209263-Carotid Arteries, pubmed-meshheading:9209263-Cell Cycle, pubmed-meshheading:9209263-Cell Division, pubmed-meshheading:9209263-Cloning, Molecular, pubmed-meshheading:9209263-Gene Expression, pubmed-meshheading:9209263-Interleukin-2, pubmed-meshheading:9209263-Ion Channel Gating, pubmed-meshheading:9209263-Lymphocyte Activation, pubmed-meshheading:9209263-Mice, pubmed-meshheading:9209263-Mice, Inbred BALB C, pubmed-meshheading:9209263-Mitogens, pubmed-meshheading:9209263-Molecular Sequence Data, pubmed-meshheading:9209263-Muscle, Smooth, Vascular, pubmed-meshheading:9209263-Potassium Channels, pubmed-meshheading:9209263-RNA, Messenger, pubmed-meshheading:9209263-Rats, pubmed-meshheading:9209263-Sequence Homology, Amino Acid, pubmed-meshheading:9209263-Spleen, pubmed-meshheading:9209263-T-Lymphocytes, Helper-Inducer
pubmed:year
1997
pubmed:articleTitle
Lymphocyte-specific inducible expression of potassium channel beta subunits.
pubmed:affiliation
Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't