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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1997-7-31
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pubmed:abstractText |
The plasma lipid response to changes in dietary fat and cholesterol can vary between individuals. The SstI polymorphism, arising from a cytosine to guanosine substitution in the 3' untranslated region of the APOC3 gene distinguishes between two alleles--S1 and S2. The S2 allele has been associated with elevated plasma triacylglycerol, cholesterol, and apolipoprotein (apo) C-III concentrations. In 90 young men we examined the effect of the same mutation on the response of low-density-lipoprotein (LDL) cholesterol to dietary monounsaturated fat. The frequency for the S2 allele was 0.14. Subjects were fed a low-fat diet for 25 d, followed by a diet rich in monounsaturated fatty acid (22% MUFA, 38% total fat) for 28 d; lipoproteins were measured at the end of each diet. There were no significant differences in initial total cholesterol between subjects with the APOC3*S1/APOC3*S1 (S1/S1) and APOC3*S1/APOC3*S2 (S1/S2) genotypes. After consumption of the diet high in MUFA, significant increases in LDL cholesterol (0.13 mmol/L, P < 0.027) were noted in the S1/S1 subjects whereas a significant decrease was observed in the S1/S2 subjects (-0.18 mmol/L, P < 0.046). Significant genotypic effects were seen for diet-induced changes in LDL cholesterol (P < 0.00034), total cholesterol (P < 0.009), and apo B (P < 0.0014). A study of the effect of the interaction between this mutation with that present in position -76 of the APOA1 gene promoter region (G/A) revealed that both mutations had an additive effect on changes in total cholesterol, LDL cholesterol, and apo B induced by diets. Plasma LDL-cholesterol responsiveness to the diet may be explained, at least in part, by variation at the APOC3 gene locus.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein A-I,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein C-III,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins C,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0002-9165
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pubmed:author |
pubmed-author:BlancoAA,
pubmed-author:CastroPP,
pubmed-author:CruzGG,
pubmed-author:JanseyFF,
pubmed-author:Jiménez-PerepérezJJ,
pubmed-author:López-MirandaJJ,
pubmed-author:López-SeguraFF,
pubmed-author:MarínCC,
pubmed-author:OrdovasJ MJM,
pubmed-author:OstosM AMA,
pubmed-author:Pérez-JiménezFF,
pubmed-author:SalasJJ
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pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
97-103
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9209175-Adult,
pubmed-meshheading:9209175-Alleles,
pubmed-meshheading:9209175-Apolipoprotein A-I,
pubmed-meshheading:9209175-Apolipoprotein C-III,
pubmed-meshheading:9209175-Apolipoproteins C,
pubmed-meshheading:9209175-Cholesterol, LDL,
pubmed-meshheading:9209175-Dietary Fats,
pubmed-meshheading:9209175-Gene Amplification,
pubmed-meshheading:9209175-Genotype,
pubmed-meshheading:9209175-Humans,
pubmed-meshheading:9209175-Male,
pubmed-meshheading:9209175-Polymorphism, Genetic
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pubmed:year |
1997
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pubmed:articleTitle |
Influence of the SstI polymorphism at the apolipoprotein C-III gene locus on the plasma low-density-lipoprotein-cholesterol response to dietary monounsaturated fat.
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pubmed:affiliation |
Unidad de Lipidos y Arteriosclerosis, Hospital Universitario Reina Sofia, Córdoba, Spain.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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