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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1997-8-25
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pubmed:abstractText |
Serotonin (5-HT) and cholecystokinin (CCK) are involved in the development of anxiety. There are only few data suggesting interactions between CCK and 5-HT under aversive conditions. In our study the cholecystokinin tetrapeptide (CCK-4) (10 microg/kg) induced 'anxious' behaviour and potentiated the increase of 5-HT release on the elevated plus maze (X-maze). The 'anxiolytic' 5-HT1A agonist 8-hydroxy-2-(di-n-propyl amino) tetralin (8-OH-DPAT; 0.3 mg/kg) reduced basal 5-HT and the increase in 5-HT release on the X-maze. 8-OH-DPAT given simultaneously with CCK-4, blocked the effects of CCK-4. The results demonstrate an interaction between CCK and 5-HT1A mechanisms via the influence on cortical 5-HT release.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
228
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
79-82
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:9209103-8-Hydroxy-2-(di-n-propylamino)tetralin,
pubmed-meshheading:9209103-Animals,
pubmed-meshheading:9209103-Anxiety,
pubmed-meshheading:9209103-Behavior, Animal,
pubmed-meshheading:9209103-Cerebral Cortex,
pubmed-meshheading:9209103-Female,
pubmed-meshheading:9209103-Guinea Pigs,
pubmed-meshheading:9209103-Maze Learning,
pubmed-meshheading:9209103-Microdialysis,
pubmed-meshheading:9209103-Receptor, Cholecystokinin B,
pubmed-meshheading:9209103-Receptors, Cholecystokinin,
pubmed-meshheading:9209103-Serotonin,
pubmed-meshheading:9209103-Serotonin Receptor Agonists,
pubmed-meshheading:9209103-Tetragastrin
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pubmed:year |
1997
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pubmed:articleTitle |
Cortical 5-HT-CCK interactions and anxiety-related behaviour of guinea-pigs: a microdialysis study.
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pubmed:affiliation |
Institute of Pharmacology and Toxicology, Medical Faculty of the Humboldt University at Berlin, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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